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alpha 1肾上腺素能受体A抗体说明书

发布时间：2025/4/17 15:34:39 阅读次数：14

产品编号：JW-0600R

英文名称：ADRA1A Rabbit pAb

中文名称：alpha 1肾上腺素能受体A抗体

英文别名：ADA1A_HUMAN; Adrenergic alpha 1A receptor; Adrenergic alpha 1C receptor; Adrenergic alpha 1D receptor; alpha 1 Adrenergic Receptor; Alpha 1A adrenergic receptor; Alpha-1A adrenergic receptor; Alpha-1A adrenoreceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c; ADRA1A; ADRA1C; Alpha 1A adrenoceptor; alpha-1A adrenergic receptor isoform 1; adrenergic, alpha-1A-, receptor variant 1; adrenergic, alpha-1A-, receptor variant 3; adrenergic, alpha-1A-, receptor variant 5; adrenergic, alpha-1A-, receptor variant 8; G protein coupled receptor; alpha-1A adrenoceptor; ADRA1L1; ALPHA1AAR.

产品应用：WB, IHC-P, IHC-F, IF, ELISA

交叉反应：Human, Mouse, Rat (predicted: Rabbit, Pig, Sheep, Cow, Chicken, Dog, GuineaPig, Horse)

抗体来源：Rabbit

免疫原：KLH conjugated synthetic peptide derived from human Alpha-1A adrenergic receptor: 201-300/466

亚型：IgG

性状：Liquid

纯化方法：affinity purified by Protein A

克隆类型：Polyclonal

理论分子量：51 kDa

浓度：1mg/ml

储存液：0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

亚基：Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.

亚细胞定位：Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.

组织特异性：Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.

翻译后修饰：C-terminal Ser or Thr residues may be phosphorylated.

相似性：Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.

SWISS：P35348

Gene ID：148

功能：This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.

保存条件：Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

注意事项：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.