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胞质接头蛋白Keap1抗体说明

发布时间：2025/4/27 11:11:23 阅读次数：8

产品编号：JW-4900R

英文名称：KEAP1 Rabbit pAb

中文名称：胞质接头蛋白Keap1

英文别名：Cytosolic inhibitor of Nrf2; INrf 2; INrf2; Keap 1; KEAP1; KEAP1_HUMAN; Kelch like ECH associated protein 1; Kelch like protein 19; Kelch-like ECH-associated protein 1; Kelch-like protein 19; KIAA0132; KLHL 19; KLHL19; MGC10630; MGC1114; MGC20887; MGC4407; MGC9454.

产品应用：WB, IHC-P, IHC-F, Flow-Cyt, ICC, IF, ELISA

交叉反应：Human, Mouse, Rat (predicted: Rabbit, Pig, Cow, Dog)

抗体来源：Rabbit

免疫原：KLH conjugated synthetic peptide derived from human KEAP1: 21-120/624

亚型：IgG

性状：Liquid

纯化方法：affinity purified by Protein A

克隆类型：Polyclonal

理论分子量：69 kDa

浓度：1mg/ml

储存液：0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

亚基：Homodimer. Forms a ternary complex with NFE2L2 and PGAM5. Interacts with the N-terminal regulatory domain of NFE2L2/NRF2. Interacts with BPTF and PTMA. Interacts with CUL3. Part of a complex that contains KEAP1, CUL3 and RBX1.

亚细胞定位：Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus.

组织特异性：Broadly expressed, with highest levels in skeletal muscle.

相似性：Contains 1 BACK (BTB/Kelch associated) domain.
Contains 1 BTB (POZ) domain.
Contains 6 Kelch repeats.

SWISS：Q14145

Gene ID：9817

功能：Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

保存条件：Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.