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核因子2相关因子2抗体说明书

发布时间：2025/4/30 9:41:51 阅读次数：171

产品编号：JW-1074R

英文名称：Nrf2 Rabbit pAb

中文名称：核因子2相关因子2抗体

英文别名：Nuclear factor-E2 related factor2; Nrf-2; HEBP1; NF E2 related factor 2; NFE2 related factor 2; NFE2L2; Nrf 2; Nuclear factor erythroid 2 related factor 2; Nuclear factor erythroid derived 2 like 2; NF2L2_HUMAN.

产品应用：WB, IHC-P, IHC-F, ICC, IF, ELISA

交叉反应：Human, Mouse, Rat (predicted: Rabbit, Pig, Cow, Chicken, Dog, Horse)

抗体来源：Rabbit

免疫原：KLH conjugated synthetic peptide derived from human Nrf2: 401-500/605

亚型：IgG

性状：Liquid

纯化方法：affinity purified by Protein A

克隆类型：Polyclonal

理论分子量：68 kDa

浓度：1mg/ml

储存液：0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

亚基：Heterodimer. Forms a ternary complex with PGAM5 and KEAP1. May bind DNA with an unknown protein. Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1.

亚细胞定位：Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.

组织特异性：Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.

翻译后修饰：Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.

相似性：Belongs to the bZIP family. CNC subfamily.
Contains 1 bZIP domain.

SWISS：Q16236

Gene ID：4780

功能：Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

保存条件：Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.