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E3泛素蛋白连接酶HACE1抗体

发布时间：2025/7/14 12:11:05 阅读次数：38

CAT#:GV-6011R
-20℃保存

E3泛素蛋白连接酶HACE1抗体

英文别名：E3 ubiquitin-protein ligase HACE1; HACE 1; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; KIAA1320; HACE1_HUMAN.
产品应用：IHC-P=1:100-500, IHC-F=1:100-500, Flow-Cyt=2ug/Test, IF=1:100-500, ELISA=1:5000-10000
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
交叉反应：Mouse (predicted: Human, Rat, Pig, Cow, Chicken, Dog, Horse)
抗体来源：Rabbit
免疫原：KLH conjugated synthetic peptide derived from human HACE1: 75-170/909
亚型：IgG
性状：Liquid
纯化方法：affinity purified by Protein A
克隆类型：Polyclonal
理论分子量：90-102 kDa
浓度：1mg/ml
储存液：0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域：Cancer > Oncoproteins/suppressors > Tumor suppressors
Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin E3 Enzymes > Hect E3 Ligase
Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin E3 Enzymes > Other E3 Ligases
Epigenetics and Nuclear Signaling > Cell cycle > Ubiquitin ligases
Epigenetics and Nuclear Signaling > Transcription > Cancer susceptibility > Tumor Suppressors
亚基：Interacts with RARB (By similarity). Interacts with RAB1 (RAB1A, RAB1B or RAB1C), RAB4 (RAB4A or RAB4B) and RAB11 (RAB11A or RAB11B); in a GTP-dependent manner. Interacts with RAC1; in a GTP-dependent manner. Interacts with the 26S proteasomal complex through the 20S core proteasomal subunit.
亚细胞定位：Cytoplasm. Endoplasmic reticulum. A significant portion localizes to the endoplasmic reticulum.
组织特异性：Expressed in multiple tissues including heart, brain and kidney.
疾病：Note=Defects in HACE1 are a cause of Wilms tumor (WT). WT is a pediatric malignancy of kidney and one of the most common solid cancers in childhood. HACE1 is epigenetically down-regulated in sporadic Wilms tumor. Moreover, a t(5;6)(q21;q21) translocation that truncates HACE1 has been found in a child with bilateral, young-onset Wilms tumor.
相似性：Contains 6 ANK repeats.
Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
SWISS：Q8IYU2
Gene ID：57531
功能：E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
保存条件：Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.