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跨膜蛋白2样蛋白抗体说明书

发布时间：2025/7/16 9:18:28 阅读次数：7

产品编号：GV-8059R
英文名称：KIAA1199 Rabbit pAb
中文名称：跨膜蛋白2样蛋白抗体
英文别名：TMEM2L; IR2155535; KIAA1199 protein; CEMIP; CCSP1; CEMIP_HUMAN; Cell migration-inducing and hyaluronan-binding protein.
产品应用：IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
交叉反应：Human, Mouse, Rat (predicted: Rabbit, Cow, Chicken, Dog, Horse)
抗体来源：Rabbit
免疫原：KLH conjugated synthetic peptide derived from human TMEM2L/KIAA1199: 101-200/1361
亚型：IgG
性状：Liquid
纯化方法：affinity purified by Protein A
克隆类型：Polyclonal
理论分子量：109/150 kDa
浓度：1mg/ml
储存液：0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
亚基：Interacts with EPHA2 and ITPR3. Interacts with HSPA5/BIP; the interaction induces calcium leakage from the endoplasmic reticulum and cell migration. Interacts with clathrin heavy chain/CLTC.
亚细胞定位：Nucleus. Cytoplasm. Endoplasmic reticulum. Cell membrane. Membrane, clathrin-coated pit. Secreted. Note=Retained in the endoplasmic reticulum (ER) in a HSPA5/BIP-dependent manner. Colocalized with clathrin heavy chain/CLTC in clathrin-coated vesicles. Strongly detected in the cytoplasm of breast carcinoma cells, whereas poorly detected in adjacent normal epithelial cells, stromal cells, or benign breast tissues. Localized in the nucleus and cytoplasm of colon adenocarcinomas.
组织特异性：Expressed in dermal and in synovial fibroblasts. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in both ductal carcinoma and invasive breast cancer cells compared with benign epithelial cells (at protein level). Strongly expressed in brain, placenta, prostate, breast, lung and testis. Expressed in fibroblasts, epithelial cells and cancer cells. In ear, it is specifically expressed in inner ear. Expressed in cochlea and vestibule tissues. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in colon adenocarcinomas compared with normal colonic mucosas. Strongly expressed in breast cancer as compared to normal breast tissue.
翻译后修饰：N-glycosylated; glycosylation is not necessary for HA-binding.
相似性：Belongs to the TMEM2 family.
Contains 1 G8 domain.
Contains 4 PbH1 repeats.
SWISS：Q8WUJ3
Gene ID：57214
功能：Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.
保存条件：Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.