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Human papillomavirus type 45 genomic DNA
GenBank: X74479.1
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LOCUS X74479 7858 bp DNA linear VRL 18-APR-2005
DEFINITION Human papillomavirus type 45 genomic DNA.
ACCESSION X74479
VERSION X74479.1
KEYWORDS E1 gene; E2 gene; E4 gene; E6 gene; E7 gene; early protein; L1
gene; L2 gene; late protein.
SOURCE human papillomavirus 45
ORGANISM human papillomavirus 45
Viruses; Monodnaviria; Shotokuvirae; Cossaviricota;
Papovaviricetes; Zurhausenvirales; Papillomaviridae;
Firstpapillomavirinae; Alphapapillomavirus.
REFERENCE 1 (bases 1 to 7858)
AUTHORS Delius,H. and Hofmann,B.
TITLE Primer-directed sequencing of human papillomavirus types
JOURNAL Curr. Top. Microbiol. Immunol. 186, 13-31 (1994)
PUBMED 8205838
REFERENCE 2 (bases 1 to 7858)
AUTHORS Delius,H.
TITLE Direct Submission
JOURNAL Submitted (06-AUG-1993) H. Delius, Deutsches
Krebsforschungszentrum, Abteilung ATV, Im Neuenheimer Feld 506, W
6900 Heidelberg, FRG
FEATURES Location/Qualifiers
source 1..7858
/organism="human papillomavirus 45"
/mol_type="genomic DNA"
/db_xref="taxon:10593"
/clone="insert in HindIII site of pGEM-1"
gene 102..578
/gene="E6"
CDS 102..578
/gene="E6"
/codon_start=1
/product="early protein"
/protein_id="CAA52573.1"
/db_xref="GOA:P21735"
/db_xref="InterPro:IPR001334"
/db_xref="UniProtKB/Swiss-Prot:P21735"
/translation="MARFDDPKQRPYKLPDLCTELNTSLQDVSIACVYCKATLERTEV
YQFAFKDLCIVYRDCIAYAACHKCIDFYSRIRELRYYSNSVYGETLEKITNTELYNLL
IRCLRCQKPLNPAEKRRHLKDKRRFHSIAGQYRGQCNTCCDQARQERLRRRRETQV"
gene 587..907
/gene="E7"
CDS 587..907
/gene="E7"
/codon_start=1
/product="early protein"
/protein_id="CAA52574.1"
/db_xref="GOA:P21736"
/db_xref="InterPro:IPR000148"
/db_xref="PDB:2EWL"
/db_xref="PDB:2F8B"
/db_xref="UniProtKB/Swiss-Prot:P21736"
/translation="MHGPRETLQEIVLHLEPQNELDPVDLLCYEQLSESEEENDEADG
VSHAQLPARRAEPQRHKILCVCCKCDGRIELTVESSAEDLRTLQQLFLSTLSFVCPWC
ATNQ"
gene 914..2845
/gene="E1"
CDS 914..2845
/gene="E1"
/codon_start=1
/product="early protein"
/protein_id="CAA52575.1"
/db_xref="GOA:P36728"
/db_xref="InterPro:IPR001177"
/db_xref="InterPro:IPR014000"
/db_xref="InterPro:IPR014015"
/db_xref="InterPro:IPR016393"
/db_xref="UniProtKB/Swiss-Prot:P36728"
/translation="MADPEGTDGEGTGCNGWFFVETIVEKKTGDVISDDEDETATDTG
SDMVDFIDTQLSICEQAEQETAQALFHAQEVQNDAQVLHLLKRKFAGGSKENSPLGEQ
LSVDTDLSPRLQEISLNSGHKKAKRRLFTISDSGYGCSEVEAAETQVTVNTNAENGGS
VHSTQSSGGDSSDNAENVDPHCSITELKELLQASNKKAAMLAVFKDIYGLSFTDLVRN
FKSDKTTCTDWVMAIFGVNPTVAEGFKTLIKPATLYAHIQCLDCKWGVLILALLRYKC
GKNRLTVAKGLSTLLHVPETCMLIEPPKLRSSVAALYWYRTGISNISEVSGDTPEWIQ
RLTIIQHGIDDSNFDLSDMVQWAFDNDLTDESDMAFQYAQLADCNSNAAAFLKSNCQA
KYLKDCAVMCRHYKRAQKRQMNMSQWIKYRCSKIDEGGDWRPIVQFLRYQGVEFISFL
RALKEFLKGTPKKNCILLYGPANTGKSYFGMSFIHFLQGAIISFVNSNSHFWLEPLAD
TKVAMLDDATHTCWTYFDNYMRNALDGNPISIDRKHKPLLQLKCPPILLTSNIDPAKD
NKWPYLESRVTVFTFPHAFPFDKNGNPVYEINDKNWKCFFERTWSRLDLHEDDEDADT
EGIPFGTFKCVTGQNTRPL"
gene 2769..3875
/gene="E2"
CDS 2769..3875
/gene="E2"
/codon_start=1
/product="early protein"
/protein_id="CAA52576.1"
/db_xref="GOA:P36794"
/db_xref="InterPro:IPR000427"
/db_xref="InterPro:IPR001866"
/db_xref="InterPro:IPR009021"
/db_xref="InterPro:IPR012677"
/db_xref="UniProtKB/Swiss-Prot:P36794"
/translation="MKMQTPKESLSERLSALQDKILDHYENDSKDINSQISYWQLIRL
ENAILFTAREHGITKLNHQVVPPINISKSKAHKAIELQMALKGLAQSKYNNEEWTLQD
TCEELWNTEPSQCFKKGGKTVHVYFDGNKDNCMNYVVWDSIYYITETGIWDKTAACVS
YWGVYYIKDGDTTYYVQFKSECEKYGNSNTWEVQYGGNVIDCNDSMCSTSDDTVSATQ
IVRQLQHASTSTPKTASVGTPKPHIQTPATKRPRQCGLTEQHHGRVNTHVHNPLLCSS
TSNNKRRKVCSGNTTPIIHLKGDKNSLKCLRYRLRKYADHYSEISSTWHWTGCNKNTG
ILTVTYNSEVQRNTFLDVVTIPNSVQISVGYMTI"
gene 4236..5627
/gene="L2"
CDS 4236..5627
/gene="L2"
/codon_start=1
/product="late protein"
/protein_id="CAA52577.1"
/db_xref="GOA:P36761"
/db_xref="InterPro:IPR000784"
/db_xref="UniProtKB/Swiss-Prot:P36761"
/translation="MVSHRAARRKRASATDLYRTCKQSGTCPPDVINKVEGTTLADKI
LQWSSLGIFLGGLGIGTGSGSGGRTGYVPLGGRSNTVVDVGPTRPPVVIEPVGPTDPS
IVTLVEDSSVVASGAPVPTFTGTSGFEITSSGTTTPAVLDITPTVDSVSISSTSFTNP
AFSDPSIIEVPQTGEVSGNIFVGTPTSGSHGYEEIPLQTFASSGSGTEPISSTPLPTV
RRVRGPRLYSRANQQVRVSTSQFLTHPSSLVTFDNPAYEPLDTTLSFEPTSNVPDSDF
MDIIRLHRPALSSRRGTVRFSRLGQRATMFTRSGKQIGGRVHFYHDISPIAATEEIEL
QPLISATNDSDLFDVYADFPPPASTTPSTIHKSFTYPKYSLTMPSTAASSYSNVTVPL
TSAWDVPIYTGPDIILPSHTPMWPSTSPTNASTTTYIGIHGTQYYLWPWYYYFPKKRK
RIPYFFADGFVAA"
gene 5530..7149
/gene="L1"
CDS 5530..7149
/gene="L1"
/codon_start=1
/product="late protein"
/protein_id="CAA52578.1"
/db_xref="GOA:P36741"
/db_xref="InterPro:IPR002210"
/db_xref="InterPro:IPR011222"
/db_xref="UniProtKB/Swiss-Prot:P36741"
/translation="MAHNIIYGHGIIIFLKNVNVFPIFLQMALWRPSDSTVYLPPPSV
ARVVSTDDYVSRTSIFYHAGSSRLLTVGNPYFRVVPNGAGNKQAVPKVSAYQYRVFRV
ALPDPNKFGLPDSTIYNPETQRLVWACVGMEIGRGQPLGIGLSGHPFYNKLDDTESAH
AATAVITQDVRDNVSVDYKQTQLCILGCVPAIGEHWAKGTLCKPAQLQPGDCPPLELK
NTIIEDGDMVDTGYGAMDFSTLQDTKCEVPLDICQSICKYPDYLQMSADPYGDSMFFC
LRREQLFARHFWNRAGVMGDTVPTDLYIKGTSANMRETPGSCVYSPSPSGSIITSDSQ
LFNKPYWLHKAQGHNNGICWHNQLFVTVVDTTRSTNLTLCASTQNPVPSTYDPTKFKQ
YSRHVEEYDLQFIFQLCTITLTAEVMSYIHSMNSSILENWNFGVPPPPTTSLVDTYRF
VQSVAVTCQKDTTPPEKQDPYDKLKFWTVDLKEKFSSDLDQYPLGRKFLVQAGLRRRP
TIGPRKRPAASTSTASTASRPAKRVRIRSKK"
ORIGIN
1 aatactttta acaattatac tacataaaaa agggtgtaac cgaaaacggt tgcaaccaaa
61 aacggtgcat ataaaagctt tgtggaaaag tgcattacag gatggcgcgc tttgacgatc
121 caaagcaacg accctacaag ctaccagatt tgtgcacaga attgaataca tcactacaag
181 acgtatctat tgcctgtgta tattgcaaag caacattgga acgcacagag gtatatcaat
241 ttgcttttaa agatttatgt atagtgtata gagactgtat agcatatgct gcatgccata
301 aatgtataga cttttattcc agaattagag aattaagata ttattcaaac tctgtatatg
361 gagagacact ggaaaaaata actaatacag agttgtataa tttgttaata aggtgcctgc
421 ggtgccagaa accattgaac ccagcagaaa aacgtagaca ccttaaggac aaacgaagat
481 ttcacagcat agctggacag taccgagggc agtgtaatac atgttgtgac caggcacggc
541 aagaaagact tcgcagacgt agggaaacac aagtatagca ataagtatgc atggaccccg
601 ggaaacactg caagaaattg tattgcattt ggaacctcag aatgaattag atcctgttga
661 cctgttgtgt tacgagcaat taagcgagtc agaggaggaa aacgatgaag cagatggagt
721 tagtcatgca caactaccag cccgacgagc cgaaccacag cgtcacaaaa ttttgtgtgt
781 atgttgtaag tgtgacggca gaattgagct tacagtagag agctcggcag aggaccttag
841 aacactacag cagctgtttt tgagcacctt gtcctttgtg tgtccgtggt gtgcaactaa
901 ccaataatct acaatggcgg atccagaagg taccgacggg gagggaacgg ggtgtaatgg
961 ctggttcttt gtagaaacaa ttgtagagaa aaaaacaggg gatgtaatat cagatgatga
1021 ggatgaaact gcaacagata cagggtcgga tatggtagat tttattgaca cacaattatc
1081 catttgtgaa caggcagagc aagagacagc acaggcattg ttccatgcgc aggaagttca
1141 gaatgatgca caggtgttgc atcttttaaa acgaaagttt gcaggaggca gcaaggaaaa
1201 cagtccatta ggggagcagc taagtgtgga tacggatcta agtccacggt tacaagaaat
1261 ttcattaaat agtgggcaca aaaaagcaaa acgacggttg tttacaatat cagatagtgg
1321 ctatggctgt tctgaagtgg aagctgcaga gactcaggta actgtaaaca ctaatgcgga
1381 aaatggcggc agtgtacata gtacacaaag tagtggtggg gatagtagtg acaatgcaga
1441 aaatgtagat ccgcattgca gtattacaga actaaaggag ctattacaag caagtaacaa
1501 aaaggctgca atgctggcag tatttaaaga catatatggg ctgtcattta cggatttggt
1561 tagaaatttt aaaagtgata aaacaacatg tacagattgg gtaatggcta tatttggagt
1621 taatccaacg gtagcagaag gctttaaaac attaattaaa ccagcaacgt tatacgccca
1681 tatccaatgt ttagattgta aatggggagt attaatatta gctttattaa gatataaatg
1741 tggcaaaaat agactaactg ttgcaaaagg cttaagcaca ttgttgcacg tacctgaaac
1801 atgtatgtta attgaaccac caaaattgcg aagtagtgtt gcagcattat actggtatag
1861 aacaggtata tccaatatta gtgaagtaag tggagacaca cctgagtgga tacaaagact
1921 gacaattatt caacatggta ttgacgatag taattttgat ttgtcagaca tggtgcaatg
1981 ggcatttgat aatgacctta cagatgaaag tgatatggca tttcaatatg cccaattagc
2041 agactgcaac agtaatgcag ctgcattttt aaaaagtaac tgccaagcca aatatttaaa
2101 agattgtgct gtaatgtgta gacattataa aagagcacaa aaacgccaaa tgaatatgtc
2161 tcaatggatt aaatatagat gttccaaaat agatgaaggt ggggattgga gacccatagt
2221 acaattccta agatatcagg gagtagaatt tattagcttt ttaagggcac taaaggaatt
2281 tcttaaagga acaccaaaaa aaaattgtat actgttatat ggacctgcaa atacaggaaa
2341 atcgtatttt ggaatgagtt ttatacattt cctacaaggt gcaataatat catttgtaaa
2401 ttcaaacagc catttttggt tagaaccgtt agcagatact aaggtagcca tgttggatga
2461 tgccacacac acgtgttgga catattttga taattatatg agaaatgcat tagatggtaa
2521 tcctataagt atagacagaa agcataaacc attattacag ctaaaatgtc ctccaatcct
2581 attaacatcc aatattgatc cagcaaaaga taataaatgg ccatatttag aaagtagggt
2641 gacggtattt acatttccac atgcatttcc atttgataaa aatggtaatc cagtatatga
2701 aataaatgat aaaaattgga aatgtttttt tgaaaggaca tggtccagat tagatttgca
2761 cgaggacgat gaagatgcag acaccgaagg aatccctttc ggaacgttta agtgcgttac
2821 aggacaaaat actagaccac tatgaaaatg acagtaaaga cataaacagc caaataagtt
2881 attggcaact tatacgtttg gaaaatgcaa tactatttac agcaagggaa catggtatta
2941 ccaaactaaa ccaccaggtg gtgcctccta ttaacatttc aaaaagcaaa gcacataaag
3001 ctattgaact gcaaatggcc ttaaagggcc ttgcacaaag caagtataac aatgaggaat
3061 ggacactgca agatacatgc gaggaactat ggaatacaga accgtcgcag tgttttaaaa
3121 aaggcggtaa aaccgtgcac gtatactttg atggcaacaa ggacaactgt atgaactatg
3181 tagtatggga cagtatatat tatataactg agacagggat atgggacaaa acagcagcat
3241 gtgttagcta ttggggtgta tattatataa aagatggaga taccacatat tatgtacaat
3301 ttaaaagcga atgtgagaaa tatggaaata gtaatacgtg ggaagtacaa tatgggggca
3361 atgtaattga ttgtaatgac tctatgtgca gtaccagtga cgacacggta tccgctactc
3421 agattgttag acagctacaa cacgcctcca cgtcgacccc caaaaccgca tccgtgggca
3481 ccccaaaacc ccacatccag acgccggcta ctaagcgacc tagacagtgt ggactcacag
3541 agcagcacca cggacgtgtc aacacccacg tgcacaaccc gctcctgtgt tcaagtacaa
3601 gtaacaacaa aagaaggaaa gtgtgtagtg gtaacactac gcctataata cacttaaaag
3661 gtgacaaaaa cagtttgaaa tgtttaagat ataggctacg caaatatgca gaccattact
3721 cagaaatatc ctccacctgg cattggacag gttgtaataa aaacactggt atattaactg
3781 taacatataa tagtgaggta caaagaaata cctttttgga tgtagttact attcctaaca
3841 gtgtacaaat ctcggtggga tacatgacta tatgaatctg tatattgtat acagtatgta
3901 acattactat gctatcttta gtgtttttat tgtgcttttc tgtgtgcctt tatgtgtgct
3961 gcaatgtccc gcttgtgcag tctgtctatg tgtgtgcttt tgcttggttg ttggtgtttc
4021 tttttatagt tgttattaca tccccattaa cagcatttgc tgtatacatt tgttgctatt
4081 tactacctat gtttgtatta catatgcatg ctttacacac catacaataa ttactataat
4141 gtacagtaca gtgtaacata cctgtgatgt gcatgttgtt gtatttttgt atttttgtat
4201 ttttgtattt ttgtatttta tatgtttaat aaaccatggt atcccaccgt gcagcacgtc
4261 gcaagcgggc ctctgcaact gacttatata gaacatgtaa gcaatccggt acgtgccccc
4321 ctgatgttat taacaaagtg gaaggcacaa ccttagctga taaaatttta cagtggtcta
4381 gccttgggat atttttgggt ggccttggca ttggtaccgg cagtggttct ggaggccgta
4441 cgggctatgt acccttaggg ggcaggtcta atactgttgt ggatgttggc cccactaggc
4501 cacctgtggt tattgaacct gtagggccta ctgatccatc tattgttacg ttggtagagg
4561 attccagtgt tgttgcctct ggtgctccgg ttcccacatt taccggaacc tctgggtttg
4621 aaattacgtc ttctggtact accacaccag ctgtgttgga catcacacct accgtggact
4681 ctgtttctat ttcgtcaact agttttacaa atcctgcatt ttctgatccc tctattattg
4741 aggtgcccca aacaggggag gtatcaggta atatatttgt tggtacacca acatcgggca
4801 gccatggata tgaggaaata cctttacaaa catttgcatc ttctgggtca ggtacggaac
4861 ccattagtag tacccccctc cctactgtgc ggcgggtacg gggtccccgc ctgtatagta
4921 gggctaatca acaggtccgt gtgtccacct cacagttttt aacacatccc tcatcgttgg
4981 ttacatttga taatccagct tatgagcccc tggacaccac actatccttt gagcctacca
5041 gtaatgttcc tgattccgat tttatggata ttattcgttt gcataggcca gcattatcct
5101 ctagacgtgg cactgttaga tttagtagat tgggtcaaag ggcaaccatg tttacacgta
5161 gtggtaaaca aatagggggt agggtacatt tttaccatga tataagcccc attgctgcta
5221 cagaggaaat tgaattgcag cctttaatta gtgctacaaa tgatagtgac ctgtttgatg
5281 tatatgcaga cttcccacct cctgcgtcca ctacacctag cactatacac aaatcattta
5341 catatccaaa gtattccttg accatgcctt ctactgctgc atcctcttac agtaatgtta
5401 cagtaccatt aacatctgca tgggatgtac ctatatatac tggcccggac attatattgc
5461 catcccatac tcctatgtgg cctagtacat ctcctaccaa tgcttccacc accacctata
5521 taggtattca tggcacacaa tattatttat ggccatggta ttattatttt cctaaaaaac
5581 gtaaacgtat tccctatttt tttgcagatg gctttgtggc ggcctagtga cagtacggta
5641 tatcttccac caccttctgt ggccagagtt gtcagcactg atgattatgt gtctcgcaca
5701 agcatatttt atcatgcagg cagttcccga ttattaactg taggcaatcc atattttagg
5761 gttgtaccta atggtgcagg taataaacag gctgttccta aggtatccgc atatcagtat
5821 agggtgttta gagtagcttt acccgatcct aataaatttg gattacctga ttctactata
5881 tataatcctg aaacacaacg tttggtttgg gcatgtgtag gtatggaaat tggtcgtggg
5941 cagcctttag gtattggcct aagtggccat ccattttata ataaattgga tgatacagaa
6001 agtgctcatg cagctacagc tgttattacg caggatgtta gggataatgt gtcagttgat
6061 tataagcaaa cacagctgtg tattttaggt tgtgtacctg ctattggtga gcactgggcc
6121 aagggcacac tttgtaaacc tgcacaattg caacctggtg actgtcctcc tttggaactt
6181 aaaaacacca ttattgagga tggtgatatg gtggatacag gttatggggc aatggatttt
6241 agtacattgc aggatacaaa gtgcgaggtt ccattagaca tttgtcaatc catctgtaaa
6301 tatccagatt atttgcaaat gtctgctgat ccctatgggg attctatgtt tttttgccta
6361 cgccgtgaac aactgtttgc aagacatttt tggaataggg caggtgttat gggtgacaca
6421 gtacctacgg acctatatat taaaggcact agcgctaata tgcgtgaaac ccctggcagt
6481 tgtgtgtatt ccccttctcc cagtggctct attattactt ctgattctca attatttaat
6541 aagccatatt ggttacataa ggcccagggc cataacaatg gtatttgttg gcataatcag
6601 ttgtttgtta ctgtagtgga cactacccgc agtactaatt taacattatg tgcctctaca
6661 caaaatcctg tgccaagtac atatgaccct actaagttta agcagtatag tagacatgtg
6721 gaggaatatg atttacagtt tatttttcag ttgtgcacta ttactttaac tgcagaggtt
6781 atgtcatata tccatagtat gaatagtagt atattagaaa attggaattt tggtgtccct
6841 ccaccaccta ctacaagttt ggtggataca tatcgttttg tgcaatcagt tgctgttacc
6901 tgtcaaaagg atactacacc tccagaaaag caggatccat atgataaatt aaagttttgg
6961 actgttgacc taaaggaaaa attttcctcc gatttggatc aatatcccct tggtcgaaag
7021 tttttagttc aggctgggtt acgtcgtagg cctaccatag gacctcgtaa gcgtcctgct
7081 gcttccacgt ctactgcatc tactgcatct aggcctgcca aacgtgtacg tatacgtagt
7141 aagaaataat atgttagcac atatatgtat gtttgtatgt atggttttgt atgttgtatg
7201 tatgtatgta tttgtgtgat atattactgt attttgtttg tttgcgtgcg tgtatgtatg
7261 aatgtgcctt gtggcatgta tggtgttact gtacataatt gtggtattaa ataaagtatg
7321 ctaatagtgt tgtgtagggt tgcacccttg tgagtaacaa tactatttgt gtgtatgtgt
7381 attgctttgt accctatatt ctttcctgta tttcaagtta taaacttgca tactacacag
7441 catccatttt acttataatc ctccattttg ctgtgcaacc gatttcggtt gcctgtggct
7501 tatatgtgac cttttaaaca taatacctaa actggcacat ttacaacccc tacatagttt
7561 aacctactgg cgcgccttct tggcgtacat gtggcacacc tggtattagt cattttcctg
7621 tccaggtgta ctaaaacaat ggcttgcaca actgtatcca caccctatgt aataaaactg
7681 cttttaggca catattttag tctgttttta cctgtgctaa ttgtataatt ggcgtgtaga
7741 accactttct tatccaacaa tctgtctact tgttacataa actataaact gactcactta
7801 tacatacata gtttatgcaa ccgaaaaagg ttgggcccta taacacatac cttttctt
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