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Human papillomavirus ORFs
GenBank: M62849.1
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LOCUS PPHT39 7833 bp DNA circular VRL 26-JAN-2001
DEFINITION Human papillomavirus ORFs.
ACCESSION M62849 M38185
VERSION M62849.1
KEYWORDS intraepithelial neoplasia; invasive carcinoma; papillomavirus.
SOURCE human papillomavirus 39
ORGANISM human papillomavirus 39
Viruses; Monodnaviria; Shotokuvirae; Cossaviricota;
Papovaviricetes; Zurhausenvirales; Papillomaviridae;
Firstpapillomavirinae; Alphapapillomavirus.
REFERENCE 1 (bases 1 to 7833)
AUTHORS Volpers,C. and Streeck,R.E.
TITLE Genome organization and nucleotide sequence of human papillomavirus
type 39
JOURNAL Virology 181 (1), 419-423 (1991)
PUBMED 1847266
FEATURES Location/Qualifiers
source 1..7833
/organism="human papillomavirus 39"
/mol_type="genomic DNA"
/db_xref="taxon:10588"
5'UTR join(7161..7833,1..106)
/standard_name="LCR"
regulatory 33..42
/regulatory_class="promoter"
/note="putative"
protein_bind 43..54
/note="putative"
/bound_moiety="E2"
/function="gene transcription"
protein_bind 59..70
/note="putative"
/bound_moiety="E2"
/function="gene transcription"
regulatory 74..80
/regulatory_class="TATA_box"
/note="putative"
gene 107..583
/gene="E6"
CDS 107..583
/gene="E6"
/note="putative"
/codon_start=1
/product="transforming protein"
/protein_id="AAA47050.1"
/translation="MARFHNPAERPYKLPDLCTTLDTTLQDITIACVYCRRPLQQTEV
YEFAFSDLYVVYRDGEPLAACQSCIKFYAKIRELRYYSDSVYATTLENITNTKLYNLL
IRCMCCLKPLCPAEKLRHLNSKRRFHKIAGSYTGQCRRCWTTKREDRRLTRRETQV"
gene 592..921
/gene="E7"
CDS 592..921
/gene="E7"
/note="putative"
/codon_start=1
/product="transforming protein"
/protein_id="AAA47051.1"
/translation="MRGPKPTLQEIVLDLCPYNEIQPVDLVCHEQLGESEDEIDEPDH
AVNHQHQLLARRDEPQRHTIQCSCCKCNNTLQLVVEASRDTLRQLQQLFMDSLGFVCP
WCATANQ"
gene 928..2871
/gene="E1"
CDS 928..2871
/gene="E1"
/note="putative"
/codon_start=1
/product="replication protein"
/protein_id="AAA47052.1"
/translation="MANREGTDGDGSGCNGWFLVQAIVDKQTGDTVSEDEDENATDTG
SDLADFIDDSTDICVQAERETAQVLLHMQEAQRDAQAVRALKRKYTDSSGDTRPYGKK
VGRNTRGTLQEISLNVSSTQATQTVYSVPDSGYGNMEVETAEVEEVTVATNTNGDAEG
EHGGSVREECSSVDSAIDSENQDPKSPTAQIKLLLQSNNKKAAMLTQFKETYGLSFTD
LVRTFKSDKTTCTDWVAAIFGVHPTIAEGFKTLINKYALYTHIQSLDTKQGVLILMLI
RYTCGKNRVTVGKGLSTLLHVPESCMLLEPPKLRSPVAALYWYRTGISNISVVTGDTP
EWIQRLTVIQHGIDDSVFDLSDMVQWAFDNEYTDESDIAFNYAMLADCNSNAAAFLKS
NCQAKYVKDCATMCKHYKRAQKRQMSMSQWIKFRCSKCDEGGDWRPIVQFLRYQGIEF
ISFLCALKEFLKGTPKKNCIVIYGPANTGKSHFCMSLMHFLQGTVISYVNSTSHFWLE
PLADAKLAMLDDATGTCWSYFDNYMRNALDGYAISLDRKYKSLLQMKCPPLLITSNTN
PVEDDRWPYLRSRLTVFKFPNAFPFDQNRNPVYTINDKNWKCFFEKTWCRLDLQQDED
EGDNDENTFTTFKCVTGQNTRIL"
gene 2798..3910
/gene="E2"
CDS 2798..3910
/gene="E2"
/note="putative"
/codon_start=1
/product="regulatory protein"
/protein_id="AAA47053.1"
/translation="MKETMMKTLSQRLNVLQDKILEYYEQDSKSIYDQINYWKCVRME
NAIFYAARERGMHTIDHQVVPTINISKCKAYQAIELQMALESVAQTEYNTEEWTLKDT
SNELWHTQPKQCFKKQGTTVEVWYDGDKCNAMNYVLWGAIYYKNNIDIWCKTEGCVDY
WGIYYMNEHLKVYYEVFIQDAERYGTSGKWEVHYNGNIIHCPDSMCSTSDGSVPTTEL
TTELSNTTATHSTATTPCTQKTIPPPSRKRPRQCAVTEPTEPDGVSLDHLNNPLHSNS
TGHNTRRYLSCGNTTPIIHLKGDKNGLKCLRYRLQKYDTLFENISCTWHWIRGKGTKN
AGILTVTYATESQRQKFLDTVKIPSSVHVSLGYMTL"
gene 3393..3677
/gene="E4"
CDS <3393..3677
/gene="E4"
/note="putative"
/codon_start=1
/product="E4 ORF"
/protein_id="AAA47049.1"
/translation="FIVLTLCAVPVTDRYPLLNLLPNYQTPPRPIPPQQPHAPKKQSR
RRLESDLDSVQSQSPLSPTECPWTILTTHSTVTVQATTQDGTSVVVTLRL"
gene 3958..4176
/gene="E5"
CDS 3958..4176
/gene="E5"
/note="putative"
/codon_start=1
/product="E5 ORF"
/protein_id="AAA47054.1"
/translation="MILLVFLVWFGVCIYICCNVPLLPSVHVCAYVWIIVFVFILIRT
TPLEVFFVYLLFFVLPMWLLHRLAMDMI"
regulatory 4243..4248
/regulatory_class="polyA_signal_sequence"
gene 4250..5662
/gene="L2"
CDS 4250..5662
/gene="L2"
/note="putative"
/codon_start=1
/product="minor capsid protein"
/protein_id="AAA47055.1"
/translation="MVSHRAARRKRASATDLYRTCKQSGTCPPDVVDKVEGTTLADKI
LQWTSLGIFLGGLGIGTGTGTGGRTGYIPLGGRPNTVVDVSPARPPVVIEPVGPSEPS
IVQLVEDSSVITSGTPVPTFTGTSGFEITSSSTTTPAVLDITPSSGSVQITSTSYTNP
AFTDPSLIEVPQTGETSGNIFVSTPTSGTHGYEEIPMEVFATHGTGTEPISSTPTPGI
SRVAGPRLYSRAHQQVRVSNFDFVTHPSSFVTFDNPAFEPVDTTLTYEAADIAPDPDF
LDIVRLHRPALTSRKGTVRFSRLGKKATMVTRRGTQIGAQVHYYHDISSIAPAESIEL
QPLVHAEPSDASDALFDIYADVDNNTYLDTAFNNTRDSGTTYNTGSLPSVASSASTKY
ANTTIPFSTSWNMPVNTGPDIALPSTTPQLPLVPSGPIDTTYAITIQGSNYYLLPLLY
FFLKKRKRIPYFFSDGYVAV"
gene 5643..7160
/gene="L1"
CDS 5643..7160
/gene="L1"
/note="L1 ORF from bp 5610 to 7160; putative"
/codon_start=1
/product="major capsid protein"
/protein_id="AAA47056.1"
/translation="MAMWRSSDSMVYLPPPSVAKVVNTDDYVTRTGIYYYAGSSRLLT
VGHPYFKVGMNGGRKQDIPKVSAYQYRVFRVTLPDPNKFSIPDASLYNPETQRLVWAC
VGVEVGRGQPLGVGISGHPLYNRQDDTENSPFSSTTNKDSRDNVSVDYKQTQLCIIGC
VPAIGEHWGKGKACKPNNVSTGDCPPLELVNTPIEDGDMIDTGYGAMDFGALQETKSE
VPLDICQSICKYPDYLQMSADVYGDSMFFCLRREQLFARHFWNRGGMVGDAIPAQLYI
KGTDIRANPGSSVYCPSPSGSMVTSDSQLFNKPYWLHKAQGHNNGICWHNQLFLTVVD
TTRSTNFTLSTSIESSIPSTYDPSKFKEYTRHVEEYDLQFIFQLCTVTLTTDVMSYIH
TMNSSILDNWNFAVAPPPSASLVDTYRYLQSAAITCQKDAPAPEKKDPYDGLKFWNVD
LREKFSLELDQFPLGRKFLLQARVRRRPTIGPRKRPAASTSSSSATKHKRKRVSK"
protein_bind 6367..6381
/gene="L1"
/standard_name="glucocorticoid responsive element"
/note="putative"
/bound_moiety="hormone receptor"
regulatory 7261..7266
/regulatory_class="polyA_signal_sequence"
protein_bind 7425..7439
/standard_name="glucocorticoid responsive element"
/note="putative"
/bound_moiety="hormone receptor"
protein_bind 7456..7467
/note="putative"
/bound_moiety="E2"
/function="gene transcription"
protein_bind 7798..7809
/note="putative"
/bound_moiety="E2"
/function="gene transcription"
ORIGIN
1 cttataacat tttataagta tcttgtttaa aaaaagggag taaccgaaaa cggtcaggac
61 cgaaatcggt ggatataaaa cgcagtcaca gtttctgtcc ataccgatgg cgcgatttca
121 caatcctgca gaacggccat acaaattgcc agacctgtgc acaacgctgg acaccacctt
181 gcaggacatt acaatagcct gtgtctattg cagacgacca ctacagcaaa ccgaggtata
241 tgaatttgca tttagtgatt tatatgtagt atatagggac ggggaaccac tagctgcatg
301 ccaatcatgt ataaaatttt atgctaaaat acgggagcta cgatattact cggactcggt
361 gtatgcaact acattagaaa atataactaa tacaaagtta tataatttat taataaggtg
421 catgtgttgt ctgaaaccgc tgtgtccagc agaaaaatta agacacctaa atagcaaacg
481 aagatttcat aaaatagcag gaagctatac aggacagtgt cgacggtgct ggaccacaaa
541 acgggaggac cgcagactaa cacgaagaga aacccaagta taacatcaga tatgcgtgga
601 ccaaagccca ccttgcagga aattgtatta gatttatgtc cttacaatga aatacagccg
661 gttgaccttg tatgtcacga gcaattagga gagtcagagg atgaaataga tgaacccgac
721 catgcagtta atcaccaaca tcaactacta gccagacggg atgaaccaca gcgtcacaca
781 atacagtgtt cgtgttgtaa gtgtaacaac acactgcagc tggtagtaga agcctcacgg
841 gatactctgc gacaactaca gcagctgttt atggactcac taggatttgt gtgtccgtgg
901 tgtgcaactg caaaccagta acctgctatg gccaatcgtg aaggtacaga cggggatggg
961 tcgggatgta acggatggtt tctagtacag gcaatagtag ataaacaaac aggcgacaca
1021 gtgtcggagg atgaggatga aaatgcaaca gatacaggtt cagacctggc agactttatt
1081 gatgattcca cagatatttg tgtacaggca gagcgtgaga cagcacaggt acttttacat
1141 atgcaagagg cccaaaggga tgcacaagca gtgcgtgcct taaaacgaaa gtatacagac
1201 agcagtggcg acactagacc gtatggaaaa aaagtaggca ggaataccag gggaacacta
1261 caggaaattt cattaaatgt aagcagtacg caggcaacac aaacggtgta ttccgtgcca
1321 gacagcggat atggcaatat ggaagtggaa acagctgaag tggaggaggt aactgtagca
1381 actaatacaa atggggatgc tgaaggggaa catggcggca gtgtacggga ggagtgcagt
1441 agtgtggata gtgctataga tagtgaaaac caggatccca aatctccaac tgcacaaatt
1501 aaattattgt tacaatccaa taacaaaaag gctgcaatgc taacacaatt taaagaaaca
1561 tatggactat cctttactga cctggtacgt acgtttaaaa gtgataaaac aacatgtaca
1621 gactgggtgg cagccatatt tggagtacat ccaactattg cagaaggatt taaaacatta
1681 atcaacaaat atgccttata tacacatata caaagcttag acacaaaaca aggagtacta
1741 attttaatgc taataagata tacatgtgga aaaaataggg ttactgtagg aaagggatta
1801 agtacattgt tacatgttcc agaaagttgt atgcttctgg agcctcctaa actgcgcagc
1861 cctgtagcag cactatattg gtatcgcaca ggtatatcca atattagtgt ggtaacaggg
1921 gatacgccag aatggataca acgattaact gttatacaac atggaataga tgatagtgta
1981 tttgacctat cggacatggt acaatgggca tttgacaatg aatatactga tgaaagtgac
2041 atagcattta attatgcaat gttagcagat tgtaacagta atgctgcagc ctttttaaaa
2101 agtaactgcc aggcaaaata tgtaaaagat tgtgcaacaa tgtgtaaaca ttacaagcga
2161 gcacaaaaaa ggcaaatgtc catgtctcaa tggataaaat ttaggtgtag taaatgtgat
2221 gaaggcgggg actggagacc catagtacaa ttcttaagat atcaaggaat agaatttata
2281 tcctttttat gtgcattaaa ggaattttta aagggtactc ccaaaaaaaa ctgtatagtt
2341 atatatggac ctgcgaatac aggaaagtca catttttgta tgagccttat gcatttttta
2401 cagggcacag ttatttcata tgtaaactcc accagccact tttggctaga accacttgca
2461 gatgcaaaac tagcaatgtt agatgatgca accggtacct gctggtcata tttcgataat
2521 tatatgagaa atgcattaga tgggtatgca ataagtttag ataggaaata taaaagttta
2581 ctacaaatga aatgtccacc attattaata acctccaata ccaatcctgt ggaagacgat
2641 aggtggccat atttacgtag taggctaaca gtgtttaaat ttcctaatgc atttccattt
2701 gaccaaaaca ggaatccagt gtacacaatc aatgataaaa actggaaatg tttttttgaa
2761 aagacttggt gcagattaga cttgcagcag gacgaggatg aaggagacaa tgatgaaaac
2821 actttcacaa cgtttaaatg tgttacagga caaaatacta gaatactatg aacaagacag
2881 taaatcaata tatgatcaaa ttaattattg gaaatgtgtg cgaatggaaa atgcaatatt
2941 ttatgcagca cgagaacgtg gcatgcatac tattgaccac caggtggtgc caaccataaa
3001 catttcaaaa tgtaaagcat atcaagctat tgaactgcag atggcactag aaagtgttgc
3061 acaaactgaa tacaatacag aggagtggac attaaaagac actagtaatg aactgtggca
3121 tacacagcca aaacaatgtt ttaaaaaaca aggaactaca gtggaggtgt ggtatgatgg
3181 ggacaaatgt aatgctatga actatgtatt atggggtgct atatattata aaaataatat
3241 agacatatgg tgtaaaacag aagggtgtgt ggactattgg ggtatatatt atatgaacga
3301 gcacctaaaa gtatactatg aagtgtttat tcaagatgcg gaaaggtatg ggactagtgg
3361 caaatgggaa gtgcattata atggcaacat aattcattgt cctgactcta tgtgcagtac
3421 cagtgacgga tcggtaccca ctactgaact tactaccgaa ttatcaaaca ccaccgcgac
3481 ccattccacc gcaacaaccc catgcaccca aaaaacaatc ccgccgccgt ctcgaaagcg
3541 acctcgacag tgtgcagtca cagagcccac tgagcccgac ggagtgtccc tggaccatct
3601 taacaaccca ctccacagta acagtacagg ccacaacaca agacggtacc tcagttgtgg
3661 taacactacg cctataatac atttaaaagg tgacaaaaat ggtttaaaat gtttaagata
3721 tagactacaa aaatatgaca cattgtttga aaatatttca tgtacctggc attggatacg
3781 gggtaaggga accaaaaacg ctggcatatt aactgttaca tatgccacag agtcacaacg
3841 ccaaaaattt ttggacactg ttaaaatacc ttctagtgta catgtttcat tgggttacat
3901 gacattgtaa agtatactat ggatattgtg tatgtatatt gtatacatac tacatagatg
3961 atattattgg tatttttggt gtggtttggt gtgtgtatat atatatgttg caatgtcccg
4021 cttttgccgt ctgtgcatgt gtgtgcgtat gtgtggataa ttgtgtttgt gtttattctt
4081 atacgtacca caccattgga ggtgtttttt gtatatttac tattttttgt attgcccatg
4141 tggttgttgc atagactggc aatggatatg atatagtact gtatatgtat gtgcattgtg
4201 cataactact gtacatagct ttttatattt ttttttgtta ctaataaaca tggtttccca
4261 ccgtgctgcc aggcgtaagc gtgcatctgc aactgaccta tatagaacct gtaaacaatc
4321 gggtacctgt ccaccagacg ttgttgataa agttgagggt actacacttg ctgacaaaat
4381 tttacagtgg actagtttag gtatattttt gggtgggtta ggcataggca caggtactgg
4441 tactggggga cgcacaggat atatacccct ggggggtagg cctaatactg ttgtagatgt
4501 gtctcctgca cgtccacctg tagttattga acctgttggt ccttctgagc catctattgt
4561 gcaattggtg gaggactcaa gtgttataac ctctggaaca ccagtaccaa catttacagg
4621 cacctctgga tttgaaatta cttcttcttc tactactacg cctgcggtat tggatattac
4681 accctcctct gggtctgtac aaataacctc tactagttat actaaccctg cctttacgga
4741 tccttcctta attgaggttc cccaaacagg tgaaacctcg ggtaatatat ttgtcagtac
4801 ccctacatca ggtacacatg gctatgagga aatacctatg gaagtgtttg ccacacatgg
4861 cacaggtacc gaacctatta gcagcacacc tacacctgga atcagtcgtg tggcaggacc
4921 acgtttatat agtagagcac atcagcaggt tcgtgttagt aattttgatt ttgtaactca
4981 cccttcatca tttgtaacat ttgataatcc tgcttttgag cctgttgata ctacattaac
5041 atatgaagct gctgacatag ctccagatcc ggattttctg gacattgttc gtttacatag
5101 gcctgcctta acctcgcgta aaggaacagt aaggtttagt aggcttggca aaaaggctac
5161 catggttacc cggcgtggca cacaaattgg agcgcaagta cattattacc atgacattag
5221 tagtattgct cctgctgaaa gcattgaatt acagccccta gttcacgctg agccctctga
5281 tgcttcagat gcattatttg atatatatgc tgatgtggac aataacacat atttagatac
5341 tgcatttaat aatacaaggg attcgggcac tacatataac acaggctcac taccttctgt
5401 ggcttcttca gcatctacta aatatgccaa tacaactatt ccttttagta cctcatggaa
5461 tatgcctgta aatactggtc ctgatattgc tttaccaagt actactccac agttgccatt
5521 ggtgccttct ggaccaatag acacaacata tgcaataacc attcagggtt ccaattatta
5581 tttgttgcca ttattgtatt ttttcctaaa aaaacgtaaa cgtattccct attttttttc
5641 agatggctat gtggcggtct agtgacagca tggtgtattt gcctccacct tctgtggcga
5701 aggttgtcaa tactgatgat tatgttacac gcacaggcat atattattat gctggcagct
5761 ctagattatt aacagtagga catccatatt ttaaagtggg tatgaatggt ggtcgcaagc
5821 aggacattcc aaaggtgtct gcatatcaat atagggtatt tcgcgtgaca ttgcccgatc
5881 ctaataaatt cagtattcca gatgcatcct tatataatcc agaaacacaa cgtttagtat
5941 gggcttgtgt aggggtggag gtgggcaggg gccagccatt gggtgttggt attagtggac
6001 acccattata taatagacag gatgatactg aaaactcacc attttcatca accaccaata
6061 aggacagtag ggataatgtg tctgtggatt ataaacagac acagttgtgc attataggct
6121 gtgttcccgc cattggggag cactggggta agggaaaggc atgcaagccc aataatgtat
6181 ctacggggga ctgtcctcct ttggaactag taaacacccc tattgaggat ggtgatatga
6241 ttgatactgg ctatggagct atggactttg gtgcattgca ggaaaccaaa agtgaggtgc
6301 ctttagatat ttgtcaatcc atttgtaaat atcctgatta tttgcaaatg tctgcagatg
6361 tgtatgggga cagtatgttc ttctgtttac gtagggaaca actgtttgca agacattttt
6421 ggaatcgtgg tggtatggtg ggtgacgcca ttcctgccca attgtatatt aagggcacag
6481 atatacgtgc aaaccccggt agttctgtat actgcccctc tcccagcggt tccatggtaa
6541 cctctgattc ccagttattt aataagcctt attggctaca taaggcccag ggccacaaca
6601 atggtatatg ttggcataat caattatttc ttactgttgt ggacactacc cgtagtacca
6661 actttacatt atctacctct atagagtctt ccataccttc tacatatgat ccttctaagt
6721 ttaaggaata taccaggcac gtggaggagt atgatttaca atttatattt caactgtgta
6781 ctgtcacatt aacaactgat gttatgtctt atattcacac tatgaattcc tctatattgg
6841 acaattggaa ttttgctgta gctcctccac catctgccag tttggtagac acttacagat
6901 acctacagtc tgcagccatt acatgtcaaa aggatgctcc agcacctgaa aagaaagatc
6961 catatgacgg tctaaagttt tggaatgttg acttaaggga aaagtttagt ttggaacttg
7021 atcaattccc tttgggacgt aaatttttgt tgcaggccag ggtccgcagg cgccctacta
7081 taggtccccg aaagcggcct gctgcatcca cttcctcgtc ctcagctact aaacacaaac
7141 gtaaacgtgt gtctaaataa tgcatgtgta tgccttgtta tgtgtgtgta tgttgtttgt
7201 ttccttatgt gttgagtgta tatgtgtatg tttgtaggta tgtgtgtata tgtttttgtt
7261 aataaagtat gtatgacagt ttcatgtgtg attgcacacc ctgtgactaa cagtgtattt
7321 gttttacata taataggtct gcaacatttc atacataatc tatatgccct accctaaggt
7381 gtgtttacta cctaatatgt aatttttaca ttgttgtatg cgtttctaca ttttatactt
7441 cgccattttg tggcgaccga agtcggtcgt gggttgagca ttttttttaa actagtggaa
7501 accacctttc tcagcaaaaa catgtcttta ccttaggttc accctgcata gttggcactg
7561 gtaacagttt tactggcgcg ccttattact catcatcctg tccaggtgca ctgcaacaat
7621 actttggcaa catccatatc tccaccctat gtaataaaac tgcttttagg catatatttt
7681 agctgttttt acttgcttaa ttaaatagtt ggcctgtata actacttttt gattcaggaa
7741 tgtgtcttac agtataagtt atacaagtga ctaatgtagc acacaatagt ttatgcaacc
7801 gaaataggtt gggcatacat acctatactt tta
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