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Human papillomavirus type 35 complete genome
GenBank: M74117.1
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LOCUS PPH35CG 7851 bp DNA circular VRL 10-MAY-2002
DEFINITION Human papillomavirus type 35 complete genome.
ACCESSION M74117
VERSION M74117.1
KEYWORDS complete genome; major capsid protein; minor capsid protein;
regulatory protein; replication protein; transformer protein.
SOURCE human papillomavirus 35
ORGANISM human papillomavirus 35
Viruses; Monodnaviria; Shotokuvirae; Cossaviricota;
Papovaviricetes; Zurhausenvirales; Papillomaviridae;
Firstpapillomavirinae; Alphapapillomavirus; Alphapapillomavirus 9.
REFERENCE 1 (sites)
AUTHORS Lorincz,A.T., Quinn,A.P., Lancaster,W.D. and Temple,G.F.
TITLE A New Type of Papillomavirus Associated with Cancer of the Uterine
Cervix
JOURNAL Virology 159, 187-190 (1991)
MEDLINE 87265470
REFERENCE 2 (bases 1 to 7851)
AUTHORS Marich,J.E., Pontsler,A.V., Rice,S.M., McGraw,K.A. and
Dubensky,T.W.
TITLE The phylogenetic relationship and complete nucleotide sequence of
human papillomavirus type 35
JOURNAL Virology 186 (2), 770-776 (1992)
PUBMED 1310198
COMMENT Original source text: Human papillomavirus type 35 cervical
carcinoma DNA.
FEATURES Location/Qualifiers
source 1..7851
/organism="human papillomavirus 35"
/proviral
/mol_type="genomic DNA"
/isolation_source="cervical carcinoma"
/db_xref="taxon:10587"
5'UTR join(7092..7851,1..109)
/standard_name="LCR"
/function="regulatory region"
protein_bind 17..22
/bound_moiety="Sp-1"
regulatory complement(18..26)
/regulatory_class="CAAT_signal"
protein_bind 24..35
/note="putative"
/bound_moiety="E2"
/function="gene transcription"
protein_bind 39..50
/note="putative"
/bound_moiety="E2"
/function="gene transcription"
regulatory 54..59
/regulatory_class="TATA_box"
/note="putative"
gene 110..559
/gene="E6"
CDS 110..559
/gene="E6"
/note="putative; E6 ORF from bp 59 to 559"
/codon_start=1
/product="transforming protein"
/protein_id="AAA46966.1"
/translation="MFQDPAERPYKLHDLCNEVEESIHEICLNCVYCKQELQRSEVYD
FACYDLCIVYREGQPYGVCMKCLKFYSKISEYRWYRYSVYGETLEKQCNKQLCHLLIR
CITCQKPLCPVEKQRHLEEKKRFHNIGGRWTGRCMSCWKPTRRETEV"
misc_feature 230..238
/gene="E6"
/standard_name="Splice donor"
misc_feature 405..416
/gene="E6"
/standard_name="Splice acceptor"
gene 562..861
/gene="E7"
CDS 562..861
/gene="E7"
/note="putative"
/codon_start=1
/product="transforming protein"
/protein_id="AAA46967.1"
/translation="MHGEITTLQDYVLDLEPEATDLYCYEQLCDSSEEEEDTIDGPAG
QAKPDTSNYNIVTSCCKCEATLRLCVQSTHIDIRKLEDLLMGTFGIVCPGCSQRA"
gene 868..2760
/gene="E1"
CDS 868..2760
/gene="E1"
/note="putative"
/codon_start=1
/product="replication protein"
/protein_id="AAA46968.1"
/translation="MADPAGTDEGEGTGCNGWFFVEAVVSRRTGSSVEDENEDDCDRG
EDMVDFINDTDILNIQAETETAQALFHAQEEQTHKEAVQVLKRKYASSPLSSVSLCVN
NNISPRLKAICIENKNTAAKRRLFELPDSGYGNSEVEIHEIQQVEGHDTVEQCSMGSG
DSITSSSDERHDETPTRDIIQILKCSNANAAMLAKFKELFGISFTELIRPFKSDKSTC
TDWCVAAFGIAPSVANFKHITYVYIYNVYRVHGAMVILALLRFKVEKREQQLKTIDAK
LLCISAASMLIQPPKLRSTPAALYWFKTAMSNISEVDGETPEWIQRQTVLQHSFNDAI
FDLSEMVQWAYDNDFIDDSDIAYKYAQLAETNSNACAFLKSNSQAKIVKDCATMCRHY
KRAEKREMTMSQWIKRRCAQVDDDGDWRDIVRFLRYQQVDFVAFLSALKNFLHGVPKK
NCILIYGAPNTGKSLFGMSLMHFLQGAIISYVNSKSHFWLQPLYDAKIAMLDDATSPC
GIYRPIFKKCTRWKSYISFRCKALSIVHIMPTFTYYININAGKDDRWPYLHSRVVVFT
FHNEFPFDKNGNPEYGLNDKNWKSFFSRTWCRLNLHEEEVKENDGDAFPAFKCVSGQN
TRTLRD"
gene 2693..3796
/gene="E2"
CDS 2693..3796
/gene="E2"
/function="regulation of gene expression"
/note="putative"
/codon_start=1
/product="regulatory protein"
/protein_id="AAA46969.1"
/translation="MMETLSQRLSVCQDKILEHYETDSTCLSDHIQYWKLIRLECAVF
YKAREMGIKTLNHQVVPTQAISKAKAMQAIELQLMLETLNTTEYSTEDWTLQETSIEL
YTTVPTRCLKKDVYTVEAQFDGDKQNTMHYTNWTHIYILEDSICTVVKGLVNYKGIYY
VHQGVETYYVTFREEAKKYGKKNIWEVHVGGQVIVCPESVFSSTELSTAEIATQLHAY
NTTETHTKACSVGTTETQKTNHKRLRGGTELPYNPTKRVRLSAVDSVDRGVYSTSDCT
NKDRCGSCSTTTPIVHLKGDANTLKCSRYRLGKYKALYQDASSTWRWTCTNDKKQIAI
VTLTYTTEYQRDKFLTTVKIPNTVTVSKGYMSI"
gene 3273..3563
/gene="E4"
CDS 3273..3563
/gene="E4"
/note="putative"
/codon_start=1
/product="unknown"
/protein_id="AAA46965.2"
/translation="MFVLNLYLAAQNYPLLKLLHSYTPTTPPRPIPKPAPWAPQKPRR
QITNDFEGVPSSPTTPPSECDSVPWTVLTEGSTLHLTAQTKTGVVVVVQLHL"
gene 3793..4038
/gene="E5"
CDS 3793..4038
/gene="E5"
/note="putative"
/codon_start=1
/product="E5"
/protein_id="AAA46970.1"
/translation="MIDLTASSTVLLCFLLCFCVLLCLCLLVRSLLLSVSLYSALILL
VLILWVTVATPLLAFVVSCFCIYLWMINAHAQYLAVQ"
regulatory 4159..4164
/regulatory_class="polyA_signal_sequence"
/note="putative"
gene 4184..5593
/gene="L2"
CDS 4184..5593
/gene="L2"
/note="putative; putative"
/codon_start=1
/product="minor capsid protein"
/protein_id="AAA46971.1"
/translation="MRHKRSTKRVKRASATQLYRTCKAAGTCPPDVIPKVEGNTVADQ
ILKYGSMAVFFGGLGIGSGSGTGGRSGYVPLGTTPPTAATNIPIRPPVTVESIPLDTI
GPLDSSIVSLVEETSFIESGAPVVTPRVPPTTGFTITTSTDTTPAILDVTSISTHDNP
TFTDPSVLHPPTPAETSGHFVLSSSSISTHNYEEIPMDTFIVSTDSNNITNSTPIPGS
RPTTRLGLYSKGTQQVKVVDPAFMTSPAKLITYDNPAYEGLNPDTTLQFEHEDISLAP
DPDFMDIIALHRPALTSRKGTIRYSRVGNKRTMHTRSGKAIGARVHYYQDLSSITEDI
ELQPLQHVPSSLPHTTVSTSLNDGMFDIYAPIDTEEDIIFSASSNNTLYTTSNTAYVP
SNTTIPLSSGYDIPITAGPDIVFNSNTITNSVLPVPTGPIYSIIADGGDFYLHPSYYL
LKRRRKAIPYFFADVSVAV"
gene 5574..7091
/gene="L1"
CDS 5574..7091
/gene="L1"
/note="putative"
/codon_start=1
/product="major capsid protein"
/protein_id="AAA46972.1"
/translation="MSLWRSNEATVYLPPVSVSKVVSTDEYVTRTNIYYHAGSSRLLA
VGHPYYAIKKQDSNKIAVPKVSGLQYRVFRVKLPDPNKFGFPDTSFYDPCLQRLVWAC
TGVEVGRGQPLGVGISGHPLLNKLDDTENLNKYVGNSGNSGTDNRECISMDYKQTQLC
LIGCRPPIGEHWGKGTPCNANQVKAGECPPLELLNTVLQDGDMVDTGFGAMDFTTLQA
NKSDVPLDICSSICKYPDYLKMVSEPYGDMLFFYLRREQMFVRHLFNRAGTVGETVPA
DLYIKGTTGTLPSTSYFPTPSGSMVTSDAQIFNKPYWLQRAQGHNNGICWSNQLFVTV
VDTTRSTNMSVCSAVSSSDSTYKNDNFKEYLRHGEEYDLQFIFQLCKITLTADVMTYI
HSMNPSILEDWNFGLTPPPSGTLEDTYRYVTSQAVTCQKPSAPKPKDDPLKNYTFWEV
DLKEKFSADLDQFPLGRKFLLQAGLKARPNFRLGRRAAPASTSKKSSTKRRKVKS"
repeat_region 7090..7105
repeat_region 7123..7160
protein_bind 7415..7426
/note="putative"
/bound_moiety="E2"
/function="gene transcription"
protein_bind 7477..7491
/standard_name="glucocorticoid responsive element"
/bound_moiety="hormone receptor"
protein_bind 7514..7519
/bound_moiety="NF-1"
protein_bind 7527..7532
/bound_moiety="NF-1"
protein_bind 7534..7539
/bound_moiety="NF-1"
regulatory complement(7670..7677)
/regulatory_class="enhancer"
/standard_name="keratinocyte specific enhancer
(CK-octomer)"
/note="putative"
protein_bind 7671..7676
/bound_moiety="NF-1"
protein_bind 7695..7700
/bound_moiety="NF-1"
ORIGIN
1 ccctataaaa aaaacaggga gtgaccgaaa acggtcgtac cgaaaacggt tgccataaaa
61 gcagaagtgc acaaaaaagc agaagtggac agacattgta aggtgcggta tgtttcagga
121 cccagctgaa cgaccttaca aactgcatga tttgtgcaac gaggtagaag aaagcatcca
181 tgaaatttgt ttgaattgtg tatactgcaa acaagaatta cagcggagtg aggtatatga
241 ctttgcatgc tatgatttgt gtatagtata tagagaaggc cagccatatg gagtatgcat
301 gaaatgttta aaattttatt caaaaataag tgaatataga tggtatagat atagtgtgta
361 tggagaaacg ttagaaaaac aatgcaacaa acagttatgt catttattaa ttaggtgtat
421 tacatgtcaa aaaccgctgt gtccagttga aaagcaaaga catttagaag aaaaaaaacg
481 attccataac atcggtggac ggtggacagg tcggtgtatg tcctgttgga aaccaacacg
541 tagagaaacc gaggtgtaat catgcatgga gaaataacta cattgcaaga ctatgtttta
601 gatttggaac ccgaggcaac tgacctatac tgttatgagc aattgtgtga cagctcagag
661 gaggaggaag atactattga cggtccagct ggacaagcaa aaccagacac ctccaattat
721 aatattgtaa cgtcctgttg taaatgtgag gcgacactac gtctgtgtgt acagagcaca
781 cacattgaca tacgtaaatt ggaagattta ttaatgggca catttggaat agtgtgcccc
841 ggctgttcac agagagcata atctacaatg gctgatcctg caggtacaga tgaaggggag
901 gggacgggat gtaatggatg gttttttgta gaagcagtag ttagtagacg tacgggatcc
961 agtgtagagg acgaaaatga agatgactgt gacagggggg aggatatggt ggactttata
1021 aatgatacag atatattaaa catacaggca gaaacagaga cagcacaagc attatttcat
1081 gcacaggagg agcaaacaca caaagaggct gtacaggtcc taaaacgaaa gtatgctagt
1141 agtccactta gcagcgtgag cttatgtgtt aataataaca taagtccacg tttaaaagct
1201 atttgcattg aaaataaaaa tacagcagca aagcgacgat tatttgaact accagacagc
1261 ggttatggca attctgaagt ggaaatacac gagatacaac aggtagaggg gcatgataca
1321 gttgaacaat gtagtatggg cagtggggat agtataacct ctagtagcga tgaaagacat
1381 gatgagactc caacgcgaga cataatacaa atactaaaat gtagtaatgc aaacgcagct
1441 atgttggcta aatttaaaga actatttggt attagtttta cagaacttat tagaccattt
1501 aagagtgata aatccacatg tacagattgg tgtgtggccg catttggaat agccccaagt
1561 gtggcgaact ttaaacatat aacatatgta tacatataca atgtttatcg tgttcatggg
1621 gctatggtaa ttctagcatt attacgattt aaagtcgaaa aacgagaaca acaattgaaa
1681 actattgatg ctaaattgct atgtatttca gctgcaagta tgctaataca accaccaaaa
1741 ttacgtagta ccccagctgc gttatattgg tttaaaacag caatgtcaaa tattagtgag
1801 gttgatggag aaacaccaga atggattcaa agacaaacag tattacagca tagttttaat
1861 gatgcaatat ttgacctatc tgaaatggta caatgggcat atgacaatga ttttatagat
1921 gatagtgata tagcatataa atatgcacaa ttggcagaaa ctaatagtaa tgcatgtgct
1981 tttttaaaaa gtaattcgca agctaaaatt gtaaaagatt gtgcaacaat gtgtagacat
2041 tataaacgag ctgaaaaaag agaaatgaca atgtcacagt ggattaaaag gcgatgtgca
2101 caggtggacg atgacggtga ctggagggac atagtacgat ttttaagata tcaacaagta
2161 gattttgtgg catttttatc tgcactaaaa aattttttac atggtgtgcc taaaaaaaat
2221 tgcatactaa tatatggagc accaaacaca ggtaaatcat tatttggaat gagtctaatg
2281 catttcttac aaggagctat tatatcctat gtaaattcta aaagccattt ttggttgcag
2341 ccattatatg atgccaaaat agctatgtta gatgatgcta catcgccatg tggcatatat
2401 agaccaatat ttaagaaatg cactagatgg aaatcctata tttcatttag atgtaaagca
2461 ttaagcatag tgcatataat gcccaccttt acttattaca tcaatataaa tgcaggcaaa
2521 gatgacaggt ggccatactt acatagcagg gtagtggtct ttacatttca caatgaattc
2581 ccatttgata aaaatggaaa cccagagtat gggcttaatg ataaaaactg gaaatccttt
2641 ttctcaagga cgtggtgcag attaaatttg cacgaggaag aggtcaaaga aaatgatgga
2701 gacgctttcc cagcgtttaa gtgtgtgtca ggacaaaata ctagaacatt acgagactga
2761 tagcacatgt ttgtctgatc acatacagta ttggaaactg attcgtcttg aatgtgcagt
2821 attttataaa gcaagagaaa tgggaattaa aactcttaac caccaagtgg ttccaacgca
2881 ggccatttca aaagccaaag caatgcaagc aattgaactg caattaatgt tagagacatt
2941 aaatacaact gagtatagca cagaggactg gacactgcaa gaaacaagta ttgaactata
3001 tacaacagtt cctacaagat gtttaaaaaa agatgtttat actgtggaag cacaatttga
3061 tggtgataaa caaaatacta tgcattatac taattggaca catatatata tattagagga
3121 cagtatatgt actgttgtaa agggactggt aaattataaa ggtatttatt atgtgcatca
3181 gggtgtagaa acatattatg ttacttttag ggaagaggct aaaaagtatg gaaaaaaaaa
3241 tatatgggaa gtgcatgtgg gtggtcaggt aattgtttgt cctgaatctg tatttagcag
3301 cacagaacta tccactgctg aaattgctac acagctacac gcctacaaca ccaccgagac
3361 ccataccaaa gcctgctccg tgggcaccac agaaacccag aagacaaatc acaaacgact
3421 tcgagggggt accgagctcc cctacaaccc caccaagcga gtgcgactca gtgccgtgga
3481 cagtgttgac agaggggtct actctacatc tgactgcaca aacaaagacc ggtgtggtag
3541 ttgtagtaca actacaccta tagtacattt aaaaggtgat gcaaatacat taaagtgttc
3601 aagatataga ttgggtaaat ataaagcatt gtatcaagat gcttcatcta catggagatg
3661 gacatgtaca aacgataaaa aacaaatagc aattgtaaca ttaacttaca caacagaata
3721 tcaaagggat aaatttttaa ctacagtaaa aatacctaac acagttacag tgtctaaagg
3781 atatatgtct atatgataga ccttacagct tccagtactg tgttgctgtg ctttttgttg
3841 tgcttttgtg tgcttttgtg cttgtgtctg cttgtacgtt cgctattgct atctgtgtca
3901 ttatactcag cattaatatt actggtttta atactgtggg ttactgtagc aacaccacta
3961 cttgcttttg ttgtttcttg cttttgtata tacctatgga tgattaacgc tcatgcacaa
4021 tatttggcag tacagtaatt gtatacaaac attgtgtttg gtactgtgta acatgtgtgt
4081 atggtggttt tattttttgt tgttcattgt atattttgtt tttttactgt ttttaaacat
4141 ttttatttct gtgtttttaa taaattgatc acatggtata accatgcgac acaaaaggtc
4201 tacaaaacgt gttaaacgtg catctgcaac acaactatat cgtacttgca aagctgcagg
4261 aacttgtcca ccagatgtta tacctaaggt tgagggtaat actgttgctg atcaaatttt
4321 aaaatatggc agcatggctg tgttttttgg ggggttagga attggttctg gatctggcac
4381 aggtggaaga tctggatatg ttccactggg tacaacacct ccaacggctg ccacaaacat
4441 tcctatacga ccccctgtaa ctgtggaaag tataccatta gacacaattg gccctttaga
4501 ttcttctata gtgtcattag tagaggaaac tagttttatt gagtctggtg cccctgttgt
4561 tacaccaagg gtcccaccta caacaggttt tacaataacc acatctacag ataccacacc
4621 tgctatttta gatgtgacat ccataagtac acatgataat cctactttca ctgatccttc
4681 tgttttacac ccacccacgc ctgcagaaac ttcaggtcat tttgtacttt catcatcttc
4741 tattagtaca cataattatg aagaaatccc tatggatact tttattgttt ccacagacag
4801 caataatata actaatagca cgcctattcc agggtctcgc cctacgacac gcctaggatt
4861 atatagtaaa ggtacccagc aggttaaggt tgttgaccct gcctttatga cttctcctgc
4921 aaaacttatt acatatgata atcctgcata tgaaggcctt aaccctgata caaccttaca
4981 atttgagcat gaggatatta gcttagctcc ggatcctgac tttatggaca ttatagcttt
5041 acataggcct gcactaacat ctaggaaagg cactattaga tatagtagag taggtaataa
5101 acgtactatg catacacgaa gtggaaaagc tataggggca cgggtacatt attatcagga
5161 tttaagtagt attactgaag atatagaatt acaaccctta caacatgtac catcctcttt
5221 accacatacc actgtttcaa catcattaaa tgatggtatg tttgatattt atgctcctat
5281 agatactgag gaagatatta tattttcagc atcttctaac aatactttat atactacatc
5341 taacactgca tatgttccta gcaatactac tataccatta agtagtggct atgatattcc
5401 tataacagca gggccagaca ttgtatttaa ctctaatact attactaact ctgtactacc
5461 ggtacccaca ggtcctatat attctattat tgcagatggg ggtgactttt atttacaccc
5521 tagttattat ttattaaaac gacgtcgtaa agctatccca tatttttttg cagatgtctc
5581 tgtggcggtc taacgaagcc actgtctacc tgcctccagt gtcagtgtct aaggttgtta
5641 gcactgatga atatgtaaca cgcacaaaca tctactatca tgcaggcagt tctaggctat
5701 tagctgtggg tcacccatac tatgctatta aaaaacaaga ttctaataaa atagcagtac
5761 ccaaggtatc tggtttgcaa tacagagtat ttagagtaaa attaccagat cctaataagt
5821 ttggatttcc agacacatca ttttatgatc cctgcctcca gcgtttggtt tgggcctgta
5881 caggagttga agtaggtcgt ggtcagccat taggagtagg tattagtggt catcctttat
5941 taaataaatt ggatgatact gaaaatctta ataaatatgt tggtaactct ggtaactctg
6001 gtacagataa cagggaatgc atttctatgg attataaaca aacacaattg tgtttaatag
6061 gttgtaggcc tcctataggt gaacattggg gaaaaggcac accttgtaat gctaaccagg
6121 taaaagcagg agaatgtcct cctttggagt tactaaacac tgtactacaa gacggggaca
6181 tggtagacac aggatttggt gcaatggatt ttactacatt acaagctaat aaaagtgatg
6241 ttcccctaga tatatgcagt tccatttgca aatatcctga ttatctaaaa atggtttctg
6301 agccatatgg agatatgtta tttttttatt tacgtaggga gcaaatgttt gttagacatt
6361 tatttaatag ggctggaact gtaggtgaaa cagtacctgc agacctatat attaagggta
6421 ccactggcac attgcctagt actagttatt ttcctactcc tagtggctct atggtaacct
6481 ccgatgcaca aatatttaat aaaccatatt ggttgcaacg tgcacaaggc cataataatg
6541 gtatttgttg gagtaaccaa ttgtttgtta ctgtagttga tacaacccgt agtacaaata
6601 tgtctgtgtg ttctgctgtg tcttctagtg acagtacata taaaaatgac aattttaagg
6661 aatatttaag gcatggtgaa gaatatgatt tacagtttat ttttcagtta tgtaaaataa
6721 cactaacagc agatgttatg acatatattc atagtatgaa cccgtccatt ttagaggatt
6781 ggaattttgg ccttacacca ccgccttctg gtaccttaga ggacacatat cgctatgtaa
6841 catcacaggc tgtaacttgt caaaaaccca gtgcaccaaa acctaaagat gatccattaa
6901 aaaattatac tttttgggag gttgatttaa aggaaaagtt ttctgcagac ttagatcagt
6961 ttccgttggg ccgtaaattt ttgttacaag caggactaaa ggccaggcct aattttagat
7021 taggcaggcg tgcagctcca gcatctacat ctaaaaaatc ttctactaaa cgtagaaaag
7081 taaaaagtta atgtgtaaat gtgtatgcat gtatactgtg tgttatgtgt tgtagtgctt
7141 gtatatatat tatgtgttgt ggtgcctgtt tgtgttgtac atggcgtgta aatgtgtgta
7201 taatattgtg caatgtgttg tacgtgggtg tttttgtact tagtgtgtag tagttcagta
7261 gccataaagt gatgtgtgtg tttataatta acactgtatt gttgtatgac tatggtgcac
7321 cgatatgagc ttacataatt acatgacagc tatattgtgt atataaataa tctacctcca
7381 ttttgtgtgt tagtgtcctt tacattacct ttcaaccgat ttcggttgct gttggtaagc
7441 tttatatgtt ttttacaaaa acattcctac ctcagcagaa cacttaatcc ttgtgttcct
7501 gatatatatt gtttgccaac tttatattgg cttttgccaa tctttaaact tgattcatct
7561 tgcagtatta gtcatttttc atacttgtgg tccacccaca cttgtaacac ttgtaacagt
7621 gcttttaggc acatattttt tgcatttcta aagggcttta attgcacacc ttggctttac
7681 atattatgtg tgtttgccaa caccacccta cacatcctgc caactttaag ttaaaacatg
7741 catgtaaaac attactcact gtattacaca ttgttatatg cacacaggtg tgtccaaccg
7801 atttggatta cagttttata agcatttctt tttattatag ttagtaacaa t
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