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钙粘蛋白15抗体说明书

发布时间：2024/7/17 15:37:02 阅读次数：196

产品编号：GV-11081R
英文名称：FAT3 Rabbit pAb
中文名称：钙粘蛋白15抗体
别    名：Cadherin family member 15; CDHF15; CDHR10; FAT tumor suppressor homolog 3; Fat3; FAT3_HUMAN; hFat3; Protocadherin Fat 3.
研究领域：神经生物学  细胞粘附分子  细胞骨架  跨膜蛋白
抗体来源：Rabbit
克隆类型：Polyclonal
交叉反应：(predicted: Human,Mouse,Rat,Dog,Cow,Rabbit,Sheep)
产品应用：IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量：512kDa
细胞定位：细胞膜
性    状：Liquid
浓    度：1mg/ml
免疫原：KLH conjugated synthetic peptide derived from human CDHF15/FAT3: 601-800/4589
亚    型：IgG
纯化方法：affinity purified by Protein A
缓冲液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件：Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed：PubMed
产品介绍：The cadherins represent a family of Ca2+-dependent adhesion molecules that function to mediate cell to cell binding that is critical for the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short C-terminal intracellular domain interacts with a variety of cytoplasmic proteins, including ∫-catenin, to regulate cadherin function. The cadherin superfamily includes cadherins, protocadherins, desmogleins and desmocollins. FAT3 (FAT tumor suppressor homolog 3, also known as CDHF15 or CDHR10, is a 4,589 amino acid single-pass type I membrane protein expressed in ES cells, primitive neuroectoderm, fetal brain, infant brain, adult neural tissues and prostate. Containing thirty-three cadherin domains, four EGF-like domains and one laminin G-like domain, FAT3 may participate in the interactions between neurites derived from specific subsets of neurons during development.