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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; MGF; Somatomedin-C; IGF1; IBP1 |
| 物种 | Human |
| 表达宿主 | E.coli |
| 序列信息 | Gly49-Ala118 |
| 检索号 | P05019 |
| 分子量 | 7.6 kDa |
| 表观分子量 | 9 kDa |
| 生物活性 | Measured by its ability to induce NFKB reporter gene expression in HEK 293 cell line. Measured in a serum-free cell proliferation assay using MCF?7 human breast cancer cellsThe ED50 for this effect is less than 200 ng/ ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 300mM NaAc, pH 6.5. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Insulin-Like Growth Factor I (IGF1) belongs to the family of Insulin-Like Growth Factors that are structurally homologous to proInsulin. Mature IGFs are generated by proteolytic processing of inactive precursor Proteins, which contains the N- and C-terminal propeptide regions. Mature human IGF-I consisting of 70 amino acids has 94% identity with mouse IGF-I and exhibits cross-species activity. IGF-1 binds IGF-IR, IGF-IIR, and the Insulin Receptor and plays a key role in cell cycle progression, cell proliferation and tumor progression. IGF-1 expression is regulated by growth hormone. R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arg (R) for the Glu (E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. R3 IGF-1 has been produced with the purpose of increasing biological activity. R3 IGF-1 is significantly more potent than human IGF-I in vitro.
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