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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | IGF1; IGF-1; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor I; Somatomedin C; somatomedin-C |
| 物种 | Mouse |
| 表达宿主 | E.coli |
| 序列信息 | Gly49-Ala118 |
| 检索号 | P05017 |
| 分子量 | 10.2 kDa |
| 表观分子量 | 12 kDa |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,1mM EDTA,pH8.0. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Insulin-Like Growth Factor I (IGF1) belongs to the family of Insulin-Like Growth Factors that are structurally homologous to proInsulin. Mouse IGF-I is synthesized as two precursor isoforms with alternate N- and C-terminal propeptides. These isoforms are differentially expressed by various tissues. Mature mouse IGF-I shares 94% and 99% aa sequence identity with human and rat IGF-I, respectively, and exhibits cross-species activity. It shares 60% aa sequence identity with mature mouse IGF-II. IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally. It plays an important role in muscle regeneration and tumor progression. IGF-I binds IGF-I R, IGF-II R, and the Insulin Receptor. IGF-I association with IGF binding Proteins increases its plasma half-life and modulates its interactions with Receptors.
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