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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Kit Ligand; Hematopoietic Growth Factor KL; Mast cell Growth Factor; MGF; Steel factor; Stem cell factor; SCF |
| 物种 | Rat |
| 表达宿主 | E.coli |
| 序列信息 | Gln26-Ala189 |
| 检索号 | P21581 |
| 分子量 | 19.3 kDa |
| 表观分子量 | 19.3 kDa |
| 标签 | C-6His |
| 生物活性 | Testing in progress |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | In general, recombinant Proteins are provided as lyophilized powder which are shipped at ambient temperature. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Stem cell factor (SCF), is the Ligand for the Receptor-type Protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/ SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/ SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ ERK2 and/ or MAPK3/ ERK1. KITLG/ SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5.
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