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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Aldesleukin; Interleukin 2; Interleukin-2; IL-2; IL2; T-cell Growth Factor; T cell Growth Factor; TCGF |
| 物种 | Mouse |
| 表达宿主 | E.coli |
| 序列信息 | Ala21-Gln169 |
| 检索号 | P04351 |
| 分子量 | 17.4 kDa |
| 表观分子量 | 17 kDa |
| 生物活性 | Measured in a cell proliferation assay using CTLL?2 mouse cytotoxic T cellsThe ED50 for this effect is less than 0.5 ng/ ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM Sodium Citrate, 5% Trehalose, pH4.5. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Interleukin 2 (IL 2), also termed T-cell Growth Factor, is a member of the Cytokine family which includes IL-4, IL-7, IL-9, IL-15 and IL-21. Each member of this family has a four alpha helix bundle. IL-2 signals through the IL-2 Receptor, a complex consisting of tree subunits, termed alpha, beta and gamma. The IL-2 R gamma is shared by Cytokine Receptors of all members of Cytokine family. Mature mouse IL-2 shares 56% and 73% aa sequence identity with human and rat IL-2, respectively. IL-2 is produced by CD4+ T cell, CD8+ T cells, gamma δ T cells, B cells, dendritic cells and eosinophils, and plays a vital role in key function of the immune system, tolerance and immunity, primarily via its potent stimulatory activity for T cells.Thus, IL-2 may be a key Cytokine in the natural suppression of autoimmunity.
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