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IL-1α/ IL1F1, Human, Recombinant

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产品概述

产品信息

别名Interleukin-1 Alpha; IL-1 Alpha; Hematopoietin-1; IL1A; IL1F1
物种Human
表达宿主E.coli
序列信息Ser113-Ala271
检索号P01583
分子量18 kDa
表观分子量17 kDa
生物活性 Measured by its ability to induce NFKB reporter gene expression in HEK 293 cell line.The ED50 for this effect is less than 50 pg/ mL.

产品特性

纯度>95% as determined by reducing SDS-PAGE.
内毒素< 1.0 EU per μg as determined by LAL test.
保存Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 7.5.
复融Please refer to it for detailed information.

背景介绍

Interleukin-1 alpha (IL1α) is a Cytokine member of the Interleukin-1 family. IL-1 consists of two distinct forms: IL1α and IL1β that recognize the same cell surface Receptors but are distinct Proteins with approximately 25% amino acid sequence identity. IL1α is constitutively produced by epithelial cells and plays an essential role in maintenance of skin barrier function. Upon stimulation, a wide variety of cells including osteoblasts, monocytes, macrophages can be induced to express IL1α. IL1α possesses a wide range of metabolic, physiological, haematopoietic activities, and is critically involved in the regulation of the immune responses and inflammatory responses.
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