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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Interleukin-1 Beta; IL-1 Beta; Il1b |
| 物种 | Mouse |
| 表达宿主 | E.coli |
| 序列信息 | Val118-Ser269 |
| 检索号 | P10749 |
| 分子量 | 17.4 kDa |
| 表观分子量 | 16 kDa |
| 生物活性 | Measured in a cell proliferation assay using mouse D10S cells.The ED50 for this effect is less than 20 pg/ mL. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 50mM TrisHCl, 50mM NaCl, pH 8.0. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Interleukin-1 (IL-1) designates two Proteins, IL-1α and IL-1β, which are the products of distinct genes, but recognize the same cell surface Receptors. IL-1α and IL-1β are structurally related polypeptides that show approximately 25% homology at the amino acid level. Both Proteins are produced by a wide variety of cells in response to stimuli such as those produced by inflammatory agents, infections, or microbial endotoxins. The Proteins are synthesized as 31 kDa precursors that are subsequently cleaved into Proteins with molecular weights of approximately 17.5 kDa. The specific protease responsible for the processing of IL-1β, designated Interleukin 1β-converting enzyme (ICE), has been described. Mature human and mouse IL-1β share approximately 75% amino acid sequence identity and human IL-1β has been found to be active on murine cell lines.
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