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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Interleukin-15; IL-15; IL15 |
| 物种 | Human |
| 表达宿主 | E.coli |
| 序列信息 | Asn49-Ser162 |
| 检索号 | P40933 |
| 分子量 | 12.5 kDa |
| 表观分子量 | 12 kDa |
| 生物活性 | Measured in a cell proliferation assay using CTLL?2 mouse cytotoxic T cellsThe ED50 for this effect is less than 0.5 ng/ ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.0. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Human Interleukin 15 (IL-15) is a Cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL15 Receptor (IL-15RA) with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 Receptor, but not the alpha subunit of the IL2 Receptor. IL-15 is structurally and functionally related to IL-2. Both Cytokines share some subunits of Receptors, allowing them to compete for and negatively regulate each other's activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs. Mature Human IL-15 shares 70% amino acid sequence identity with Mouse and Rat IL-15.
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