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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
别名 | Lymphotoxin-Alpha; LT-Alpha; TNF-Beta; Tumor Necrosis Factor Ligand Superfamily Member 1; LTA; TNFB; TNFSF1 |
物种 | Human |
表达宿主 | E.coli |
序列信息 | Leu35-Leu205 |
检索号 | P01374 |
分子量 | 18.8 kDa |
表观分子量 | 15 kDa |
生物活性 | Measured in a cytotoxicity assay using L?929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is less than 100 pg/ ml. |
产品特性
纯度 | >95% as determined by reducing SDS-PAGE. |
内毒素 | < 1.0 EU per μg as determined by LAL test. |
保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
复融 | Please refer to it for detailed information. |
背景介绍
Tumor Necrosis Factor β (TNF-β) is a secreted Protein belonging to the tumor necrosis factor family. TNF-β binds to TNFRSF1A/ TNFR1, TNFRSF1B/ TNFBR and TNFRSF14/ HVEM in homotrimeric form, binds to TNFRSF3/ LTBR in heterotrimeric form with LTB. TNF-β forms heterotrimers with lymphotoxin-beta, which anchors TNF-β to the cell surface. TNF-β mediates the inflammatory, immunostimulatory, and antiviral response, involves in the formation of second lymphoid organs during development, has a role in apoptosis. TNF-β is produced by lymphocytes and cytotoxic for a variety of tumor cells in vitro and in vivo.
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