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TNF-β/ TNFB/ TNFSF1, Human, Recombinant

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产品概述

产品信息

别名Lymphotoxin-Alpha; LT-Alpha; TNF-Beta; Tumor Necrosis Factor Ligand Superfamily Member 1; LTA; TNFB; TNFSF1
物种Human
表达宿主E.coli
序列信息Leu35-Leu205
检索号P01374
分子量18.8 kDa
表观分子量15 kDa
生物活性 Measured in a cytotoxicity assay using L?929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is less than 100 pg/ ml.

产品特性

纯度>95% as determined by reducing SDS-PAGE.
内毒素< 1.0 EU per μg as determined by LAL test.
保存Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
复融Please refer to it for detailed information.

背景介绍

Tumor Necrosis Factor β (TNF-β) is a secreted Protein belonging to the tumor necrosis factor family. TNF-β binds to TNFRSF1A/ TNFR1, TNFRSF1B/ TNFBR and TNFRSF14/ HVEM in homotrimeric form, binds to TNFRSF3/ LTBR in heterotrimeric form with LTB. TNF-β forms heterotrimers with lymphotoxin-beta, which anchors TNF-β to the cell surface. TNF-β mediates the inflammatory, immunostimulatory, and antiviral response, involves in the formation of second lymphoid organs during development, has a role in apoptosis. TNF-β is produced by lymphocytes and cytotoxic for a variety of tumor cells in vitro and in vivo.
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