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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | CD254; ODF; OPGL; RANKL; TNFSF11; CD254; Osteoclast differentiation factor; Receptor activator of nuclear factor kappa-B Ligand; tumor necrosis factor Ligand superfamily member 11 |
| 物种 | Human |
| 表达宿主 | E.coli |
| 序列信息 | Ile140-Asp317 |
| 检索号 | O14788 |
| 分子量 | 22.4 kDa |
| 表观分子量 | 20 kDa |
| 标签 | N-6His |
| 生物活性 | Measured by its ability to binding SF11A used funtional ELISAThe ED50 for this effect is less than 10 ug/ ml. |
产品特性
| 纯度 | >90% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,pH8.0. |
| 复融 | Please refer to it for detailed information. |
背景介绍
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane Protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the Ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF Receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitogen-activated Protein kinases (MAPK), activating Protein 1 (AP-1), and nuclear factor of activated T cells (NFATc1), resulting in the formation of multinucleated bone-resorbing osteoclasts. RANKL is widely expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas.
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