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RANK/ TNFRSF11A/ CD265 (C-6His), Human, Recombinan

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产品概述

产品信息

别名CD265; ODFR; TNFRSF11A; TRANCE R; CD265; CD265 antigen; FEO; ODFROSTS; OFE; OPTB7; PDB2; RANK1; Receptor activator of NF-KB; Receptor activator of nuclear factor-kappa B; TRANCER; tumor necrosis factor Receptor superfamily member 11A
物种Human
表达宿主Human Cells
序列信息Ile30-Pro212
检索号Q9Y6Q6
分子量21.1 kDa
表观分子量25-30 kDa
标签C-6His
生物活性 Testing in progress

产品特性

纯度>95% as determined by reducing SDS-PAGE.
内毒素< 1.0 EU per μg as determined by LAL test.
保存Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复融Please refer to it for detailed information.

背景介绍

Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor Receptor (TNFR) molecular superfamily. RANK is the Receptor for RANK-Ligand (RANKL) and part of the RANK/ RANKL/ OPG signaling pathway that regulates osteoclast differentiation and activation. It plays a vital role in bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. RANK is constitutively expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoclast, mammary gland epithelial cells, prostate, vascular cell, and pancreas.
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