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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Tumor necrosis factor Ligand superfamily member 11; Tnfsf11; Osteoclast differentiation factor; ODF; Osteoprotegerin Ligand; OPGL; Receptor activator of nuclear factor kappa-B Ligand; RANKL; TNF-related activation-induced Cytokine; TRANCE; CD254 |
| 物种 | Mouse |
| 表达宿主 | Human Cells |
| 序列信息 | Ala73-Asp316 |
| 检索号 | O35235 |
| 分子量 | 28.5 kDa |
| 表观分子量 | 30-35 kDa |
| 标签 | C-6His |
| 生物活性 | Measured by its ability to bind Human TNFRSF11B in functional ELISA. The ED50 for this effect is less than 10 ug/ ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Mouse tumor necrosis factor Ligand superfamily member 11 (Tnfsf11) is a member of the tumor necrosis factor (TNF) Cytokine family. Tnfsf11 is widely expressed in cells including T cells and T cell rich organs, such as thymus and lymph nodes. This Cytokine can bind to TNFRSF11B/ OPG andTNFRSF11A/ RANK. Tnfsf11 is involved in a number of fundamental biological processes such as acting as regulator of interactions between T-cells and dendritic cells, the regulation of the T-cell-dependent immune response and enhancing bone-resorption in humoral hypercalcemia of malignancy. It augments the ability of dendritic cells to stimulate naive T-cell proliferation.
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