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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Beta-Nerve Growth Factor; Beta-NGF; NGF; NGFB |
| 物种 | Human |
| 表达宿主 | E.coli |
| 序列信息 | Glu19-Ala241 |
| 检索号 | P01138 |
| 分子量 | 25 kDa |
| 表观分子量 | 30 kDa |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2. |
| 复融 | Please refer to it for detailed information. |
背景介绍
The precursor form of the Nerve Growth Factor (proNGF) like its mature form is characterized by the cystin knot Motif consisting of three cystine bridges, whereas proneurotrophins and mature neurotrophins elicit opposite biological effects. ProNGF functions preferentially via the complex of pan-neurotrophin Receptor p75 (p75NTR) and vps10p domain-containing Receptor sortilin inducing neuronal apoptosis and contributing to age- and disease-related neurodegeneration.
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