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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Beta-Nerve Growth Factor; Beta-NGF; NGF; NGFB |
| 物种 | Mouse |
| 表达宿主 | E.coli |
| 序列信息 | Met130-Arg239 |
| 检索号 | P01139 |
| 分子量 | 12.4 kDa |
| 表观分子量 | 12 kDa |
| 生物活性 | Measured in a cell proliferation assay using TF?1 human erythroleukemic cells.The ED50 for this effect is less than 5 ng/ ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM Tris,200mM NaCl,pH8.0. |
| 复融 | Please refer to it for detailed information. |
背景介绍
NGF is the first member discovered in the Neurotrophin family, which includes brain-Derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These Proteins belong to the cysteine-knot family of Growth Factors that assume stable dimeric structures. Mouse beta -NGF is a homodimer of two 120 amino acid polypeptides. It shares approximately 90% homology at the amino acid level with human beta -NGF and 95.8% with rat beta -NGF. NGF signaling has been shown to play an important role in neuroprotection and repair. β-NGF acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival. It is a potent neurotrophic factor that signals through its Receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems.
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