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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Interleukin-7; IL-7; IL7 |
| 物种 | Human |
| 表达宿主 | E.coli |
| 序列信息 | Asp26-His177 |
| 检索号 | P13232 |
| 分子量 | 17.5 kDa |
| 表观分子量 | 18 kDa |
| 生物活性 | Measured in a cell proliferation assay using PHA-activated human peripheral blood lymphocytes (PBL).The ED50 for this effect is less than 0.4 ng/ ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Human Interleukin 7 (IL-7) is a potent lymphoid cell Growth Factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte Growth Factor (HGF) to form a hybrid Cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor Protein containing a 25 amino acid signal peptide and a 152 amino acid mature Protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 Receptor (IL7R) activating multiple pathways including JaK/ STAT and PI3K/ AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction.
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