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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Brain-Derived Neurotrophic Factor; BDNF; Abrineurin |
| 物种 | Human |
| 表达宿主 | E.coli |
| 序列信息 | His129-Arg247 |
| 检索号 | P23560 |
| 分子量 | 13 kDa |
| 表观分子量 | 14 kDa |
| 生物活性 | Measured by its ability to bind Human TrkB in functional ELISA. The ED50 for this effect is less than 5 ug/ ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase Receptor. It also binds with the LNGFR (for low-affinity Nerve Growth Factor Receptor, also known as p75). BDNF promotes the survival, growth and differentiation of neurons. It serves as a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. BDNF expression is altered in neurodegenerative disorders such as Parkinson's and Alzheimer's disease.
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