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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Erythropoietin; Epoetin; EPO |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Ala28-Arg193 |
| 检索号 | P01588 |
| 分子量 | 19.2 kDa |
| 表观分子量 | 30-40 kDa |
| 生物活性 | Measured in a cell proliferation assay using TF?1 human erythroleukemic cellsThe ED50 for this effect is less than 5 ng/ ml |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Erythropoietin (EPO) is a glyco Protein hormone that is principally known for its role in erythropoiesis,where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells.Erythropoietin is a member of the EPO/ TPO family. It is a secreted, glycosylated Cytokine composed of fouralpha helical bundles. The differentiation of CFU-E (Colony Forming Unit-Erythroid) cells into erythrocytescan only be accomplished in the presence of EPO. Physiological levels of EPO in adult mammals aremaintained primarily by the kidneys, whereas levels in fetal or neonatal mammals are maintained by theliver. EPO also can exert various non-hematopoietic activities, including vascularization and proliferation ofsmooth muscle, neural protection during hypoxia, and stimulation of certain B cells. Genetic variation inerythropoietin is associated with susceptbility to microvascular complications of diabetes type 2. These arepathological conditions that develop in numerous tissues and organs as a consequence of diabetesmellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, anddiabetic neuropathy.
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