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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Vascular Endothelial Growth Factor A; VEGF-A; Vascular Permeability Factor; VPF; VEGFA; VEGFA164; VEGF164 |
| 物种 | Mouse |
| 表达宿主 | P.pastoris |
| 序列信息 | Ala27-Arg190 |
| 检索号 | Q00731-2 |
| 分子量 | 19.3 kDa |
| 表观分子量 | 20 kDa |
| 生物活性 | Measured?in?a?cell?proliferation?assay?using?HUVEC?human?umbilical?vein?Endothelial?cells.The?ED50?for?this?effect?is?less than 4ng/ mL, Corresponding to a specific activity of ≥ 2.5×105 units/ mg. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Mouse Vascular Endothelial Growth Factor (VEGF or VEGF-A), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the PDGF/ VEGF Growth Factor family that is characterized by a cystine knot structure formed by eight conserved cysteine residues. Alternately spliced isoforms of 120, 164 and 188 aa found in mouse. VEGF binds the type I transmembrane Receptor tyrosine kinases VEGF R1 (also called Flt-1) and VEGF R2 (Flk-/ KDR) on Endothelial cells.Although affinity is highest for binding to VEGF R1, VEGF R2 appears to be the primary mediator of VEGF angiogenic activity. VEGF is required during embryogenesis to regulate the proliferation, migration, and survival of Endothelial cells.It may play a role in increasing vascular Permeability during lactation, when increased transport of molecules from the blood is required for efficient milk Protein synthesis.
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