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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Interleukin-4 Receptor subunit alpha; IL-4R-alpha; CD124; IL4-BP; Soluble IL-4R-alpha |
| 物种 | Cynomolgus |
| 表达宿主 | Human Cells |
| 序列信息 | Met26-Arg232 |
| 检索号 | G7Q0S7 |
| 分子量 | 24.6 kDa |
| 表观分子量 | 40 kDa |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Interleukin-4 Receptor subunit alpha (IL-4RA), alos known as Soluble IL-4 Receptor subunit alpha, belongs tothe type I Cytokine Receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functionsas Receptor for both Interleukin 4 and Interleukin 13 and couples to the JAK1/ 2/ 3-STAT6 pathway. The IL4response is involved in promoting Th2 differentiation. The IL4/ IL13 responses are involved in regulating IgEproduction and Chemokine and mucus production at sites of allergic inflammation. In certain cell types, IL-4RA can signal through activation of insulin Receptor substrates, IRS1/ IRS2. The functional IL4 Receptor isformed by initial binding of IL4 to IL4R. Subsequently it recruits to the complex of the common gammachain. In immune cells, IL-4RA creates a type I Receptor. In non-immune cells, it forms a type II Receptorwith of IL13RA1. IL4R can also interact with the IL13/ IL13RA1 complex to form a similar type II Receptor andinteracts with the SH2-containing phosphatases, PTPN6/ SHIP1, PTPN11/ SHIP2 and INPP5D/ SHIP.
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