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APRIL/ TNFSF13/ TRDL-1α (N-Flag-His), Human, Recom

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产品概述

产品信息

别名Tumor necrosis factor Ligand superfamily member 13; A proliferation-inducing Ligand; APRIL; TNF- and APOL-related leukocyte expressed Ligand 2; TALL-2; TNF-related death Ligand 1; TRDL-1; CD256; TNFSF13
物种Human
表达宿主Human Cells
序列信息Lys112-Leu250
检索号O75888
分子量50 kDa
表观分子量60 kDa

产品特性

纯度>90% as determined by reducing SDS-PAGE.
内毒素< 1.0 EU per μg as determined by LAL test.
保存Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
复融Please refer to it for detailed information.

背景介绍

APRIL (a proliferation-inducingLigand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF Ligand superfamily. It issynthesized as a32 kDa pro Protein which is cleaved by furin in the Golgi to release the active 17 kDa soluble molecule.Secreted human APRIL, which consists almost entirely ofa single TNF homology domain, shares 85% amino acid sequence identity with mouse and rat APRIL. BothAPRIL and its close relative BAFF bind and signalthrough the TNF superfamily Receptors TACI and BCMA, while BAFF additionally functions through BAFF R.APRIL binds to heparan sulfateproteoglycans (HSPGs) independently of its binding to TACI and BCMA.
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