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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
别名 | Tumor necrosis factor Ligand superfamily member 13; A proliferation-inducing Ligand; APRIL; TNF- and APOL-related leukocyte expressed Ligand 2; TALL-2; TNF-related death Ligand 1; TRDL-1; CD256; TNFSF13 |
物种 | Human |
表达宿主 | Human Cells |
序列信息 | Lys112-Leu250 |
检索号 | O75888 |
分子量 | 50 kDa |
表观分子量 | 60 kDa |
产品特性
纯度 | >90% as determined by reducing SDS-PAGE. |
内毒素 | < 1.0 EU per μg as determined by LAL test. |
保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
复融 | Please refer to it for detailed information. |
背景介绍
APRIL (a proliferation-inducingLigand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF Ligand superfamily. It issynthesized as a32 kDa pro Protein which is cleaved by furin in the Golgi to release the active 17 kDa soluble molecule.Secreted human APRIL, which consists almost entirely ofa single TNF homology domain, shares 85% amino acid sequence identity with mouse and rat APRIL. BothAPRIL and its close relative BAFF bind and signalthrough the TNF superfamily Receptors TACI and BCMA, while BAFF additionally functions through BAFF R.APRIL binds to heparan sulfateproteoglycans (HSPGs) independently of its binding to TACI and BCMA.
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