您好,欢迎光临上海极威生物科技商城!
分享:

GRO-β/ CINC-3/ CXCL2, Human, Recombinant

用户评价:

QQ: 435399850       微信:16602115336

【温馨提示】:产品价格与说明书请点击上面QQ或添加微信,在线询价,索要该产品说明书

订购热线:021-80186165
产品概述

产品信息

别名C-X-C Motif Chemokine 2; Growth-Regulated Protein Beta; Gro-Beta; Macrophage Inflammatory Protein 2-Alpha; MIP2-Alpha; CXCL2; GRO2; GROB; MIP2A; SCYB2
物种Human
表达宿主E.coli
序列信息Thr39-Asn107
检索号P19875
分子量7.67 kDa
表观分子量10 kDa
生物活性 Measured by its ability to activate chimeric Receptor and induce reporter gene expression in HEK293 cell line used Splite TEV activity detection platform.The ED50 for this effect is less than 10 ng/ mL.

产品特性

纯度>95% as determined by reducing SDS-PAGE.
内毒素< 1.0 EU per μg as determined by LAL test.
保存Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 400mM NaCl, pH 8.5.
复融Please refer to it for detailed information.

背景介绍

Chemokine Ligand 2 (CXCL2) is a small secreted Cytokine which belongs to the CXC Chemokine family. It is secreted by monocytes and macrophages and chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. CXCL2 mobilizes cells by interacting with a cell surface Chemokine Receptor called CXCR2. It has been known to regulate immune functions mainly by chemo-attracting neutrophils. It is produced by activated monocytes and neutrophils and expressed at sites of inflammation. It is a hematoregulatory Chemokine, which suppresses hematopoietic progenitor cell proliferation. It can be induced by Receptor activator of NF-kappaB Ligand, the osteoclast (OC) differentiation factor, through JNK and NF-kappaB signaling pathways in OC precursor cells. CXCL2 in turn enhanced the proliferation of OC precursor cells of bone marrow-Derived macrophages (BMMs) through the activation of ERK. Knockdown of CXCL2 inhibited both the proliferation of and the ERK activation in BMMs. During osteoclastogenesis CXCL2 stimulated the adhesion and the migration of BMMs. CXCL2 is a novel therapeutic target for inflammatory bone destructive diseases.
我要询价
*联系方式:
(可以是QQ、MSN、电子邮箱、电话等,您的联系方式不会被公开)
*内容:


微信客服,扫一扫立即咨询


微信客服,扫一扫立即咨询

首页|技术服务|品牌中心|新闻中心|公司介绍|联系我们


微信客服
扫一扫立即咨询


微信客服
扫一扫立即咨询

销售电话:

021-80186165

16602115336

15214379366

13148176757