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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Fibroblast Growth Factor 19; FGF-19; FGF19 |
| 物种 | Human |
| 表达宿主 | E.coli |
| 序列信息 | Phe27-Lys216 |
| 检索号 | O95750 |
| 分子量 | 23.5 kDa |
| 表观分子量 | 24 kDa |
| 标签 | N-6His |
| 生物活性 | Measured by its ability to bind Human FGF R3 in functional ELISA. The ED50 for this effect is less than 15 ug/ ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB，150mM NaCl,pH7.4. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Fibroblast Growth Factor 19 (FGF19) is a secreted Protein which belongs to the FGFs family. FGF19 is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF Receptors (FGFRs): FGFR-1, -2, -3, and -4, all with intrinsic tyrosine kinase activity. FGFRs can be important for regulation of glucose and lipid homeostasis. FGF19 has important roles as a hormone produced in the ileum in response to bile acid absorption. It has been shown to cause resistance to diet-induced obesity and insulin desensitization and to improve insulin, glucose, and lipid profiles in diabetic rodents. FGF19 can be considered as a regulator of energy expenditure.
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