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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | CD215; IL15RA; CD215 antigen; IL-15 Receptor subunit alpha; IL-15RA; IL-15R-alpha; Interleukin 15 Receptor; alpha; Interleukin-15 Receptor subunit alpha; MGC104179 |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Ile31-Thr205 |
| 检索号 | Q13261 |
| 分子量 | 45.5 kDa |
| 表观分子量 | 36-50 kDa |
| 标签 | C-Fc |
| 生物活性 | Measured by its ability to block human IL-15-induced proliferation of CTLL?2 mouse cytotoxic T cells. The ED50 for this effect is less than 10 ng/ ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glyco Protein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” Cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/ IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-bound IL-15 Receptor β and γ heterodimers and enables signaling to cells.
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