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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Interleukin-1 Receptor type 2; IL-1R-2; IL-1RT-2; IL-1RT2; CD121 antigen-like family member B; CDw121b; IL-1 type II Receptor; Interleukin-1 Receptor beta; IL-1R-beta; Interleukin-1 Receptor type II; CD121b |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Phe14-Glu343 |
| 检索号 | NP_004624.1 |
| 分子量 | 38.6 kDa |
| 表观分子量 | 50 kDa |
| 标签 | C-6His |
| 生物活性 | Immobilized human IL1R2 at 10 μg/ ml (100 μl/ well) can bind biotinylated human IL1B-His, The EC50 of biotinylated human IL1B-His is 0.14-0.34 μg/ ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Interleukin-1 Receptor type 2 (IL1R2) belongs to the Interleukin-1 Receptor family. Two distinct types of IL1 Receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1 Receptor type II is a 68 kDa transmembrane Protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. IL1R2 is non-signaling Receptor forIL1A, IL1B and IL1RN, reduces IL1B activities. IL1R2 serves as a decoy Receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/ soluble Receptors.
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