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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Interleukin-13 Receptor subunit alpha-1; IL-13 Receptor subunit alpha-1; IL-13R subunit alpha-1; IL-13R-alpha-1; IL-13RA1; Cancer/ testis antigen 19; CT19; CD213a1; IL13RA1; IL13R; IL13RA |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Gly22-Thr343 |
| 检索号 | NP_001551.1 |
| 分子量 | 37.7 kDa |
| 表观分子量 | 55-65 kDa |
| 标签 | C-6His |
| 生物活性 | Measured by its binding ability in a functional ELISA. Immobilized human IL13RA1 at 4 μg/ ml (100 μl/ well) can bind human IL13 with a linear ranger of 0.156-2.5 μg/ ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Interleukin-13 Receptor subunit alpha-1 (IL13RA1) is a subunit of the Interleukin 13 Receptor. This subunit forms a Receptor complex with IL4 Receptor alpha, a subunit shared by IL13 and IL4 Receptors. The human IL13-Rα1 was originally cloned based on sequence homology to the mouse IL13-Rα1, it share 76% aa sequence identity. Human The IL13-Rα1 cDNA encodes a 427 amino acid (aa) residue precursor Protein with a putative 21 aa residue signal peptide, a 324 aa residue extracellular domain, a 23 aa residue transmembrane region and a 59 aa residue cytoplasmic tail. The extracellular domain of IL13-Rα1 is also closely related to that of IL13-Rα2. It binds with low affinity to Interleukin-13 (IL13). IL13RA1 serves as a primary IL13- binding subunit of the IL13 Receptor, and may also be a component of IL4 Receptors. This Protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.
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