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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | IL-17A/ F Heterodimer; IL-17A&IL-17F Heterodimer |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Ile20-Ala155&Arg31-Gln163 |
| 检索号 | Q16552&Q96PD4 |
| 分子量 | 43.2 kDa |
| 表观分子量 | 15-18 kDa |
| 标签 | C-6His |
| 生物活性 | Measured by its ability to induce IL-6 secretion by NIH?3T3 mouse embryonic fibroblast cells.The ED50 for this effect is typically 0.2 ng/ mL. |
产品特性
| 纯度 | >90% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
| 复融 | Please refer to it for detailed information. |
背景介绍
The IL-17 family include IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F. The family is comprised of at least six proinflammatory Cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. All members of the IL-17 family have a similar Protein structure, with four highly conserved cysteine residues critical to their 3-dimensional shape, yet they have no sequence similarity to any other known Cytokines. IL-17 family members are glyco Proteins secreted as dimers that induce local Cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes.
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