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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Interleukin-18; Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; GIF; IL-18; IL-1g; IL1F4; MGC12320 |
| 物种 | Human |
| 表达宿主 | E.coli |
| 序列信息 | Tyr37-Asp193 |
| 检索号 | Q14116 |
| 分子量 | 18.2 kDa |
| 表观分子量 | 17 kDa |
| 生物活性 | Measured by its ability to induce NFKB reporter gene expression in HEK 293 cell line.The ED50 for this effect is less than 25ng/ mL. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Interleukin-18 is a secreted Protein and it belongs to the IL-1 family. IL-18 is a proinflammatory Cytokine and produced by macrophages and other cells. This Cytokine can induce the IFN-gamma production of T cells. The combination of this Cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding Protein (IL18BP) can specifically interact with this Cytokine, and thus negatively regulate its biological activity. After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important Cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells.
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