暂无数据
产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Interleukin-25; IL-25; Interleukin-17E; IL-17E; IL25; IL17E |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Tyr33-Gly177 |
| 检索号 | Q9H293 |
| 分子量 | 16.7 kDa |
| 表观分子量 | 20-26 kDa |
| 标签 | C-6His |
| 生物活性 | Testing in progress |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM Tris,150mM NaCl 1mM EDTA,pH8.0. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of Proteins, which is comprised of six members (IL-17, IL-17B through IL-17F). These Proteins are secreted and are structurally related by sharing a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. With the exception of IL-17B, which exists as a non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers. IL-17 family Proteins are pro-inflammatory Cytokines that induce local Cytokine production and are involved in the regulation of immune functions. Human Interleukin-17E (IL17E), also referred to as Interleukin-25 (IL25), is a distinct member of the IL17 Cytokine family comprised of at least six members sharing a conserved cysteine-knot structure but divergent at the N-terminus. IL25 is a glyco Protein secreted as dimers by innate effector eosinophils and basophils, and present at very low levels in various peripheral tissues. IL25, together with IL17B, are Ligands for the Cytokine Receptor IL17BR, and the cross-linking induces NF-κB activation and production of the proinflammatory Chemokine IL-8, as well as ERK, JNK, and p38 activation. Overexpression of IL25 gene in transgenic mice suggested that this Cytokine can regulate hematopoietic and immune functions, and additionally is identified as a proinflammatory Cytokine favoring Th2-type immune responses possibly by enhancing the maintenance and functions of adaptive Th2 memory cells.
暂无数据
我要询价
*联系方式：
(可以是QQ、MSN、电子邮箱、电话等，您的联系方式不会被公开)
*内容：
