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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Interleukin-31; IL-31; IL31 |
| 物种 | Human |
| 表达宿主 | E.coli |
| 序列信息 | Ser24-Thr164 |
| 检索号 | Q6EBC2 |
| 分子量 | 15.8 kDa |
| 表观分子量 | 15 kDa |
| 生物活性 | Measured by inducing STAT3 activation in U87 MG human glioblastoma/ astrocytoma cells.The ED50 for this effect is less than 45 ng/ mL. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Human Interleukin 31 (IL-31) is a Cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes a 164 amino acid precursor that contains a 23 amino acid signal peptide and a 141 amino acid mature Protein. Human and mouse IL-31 share 24% sequence identity in the mature region. IL-31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper T cells (Th2). IL-31 signals via a heterodimeric Receptor complex composed of a gp130 related molecule termed IL-31RA (also GPL and GLMR) and an Oncostatin M Receptor (OSM Rβ). The IL-31 Receptor is constitutively expressed by keratinocytes and upregulated by IFNγ on monocytes. GPL/ OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Studies have shown that IL31 induces severe pruritis (itching) and dermatitis in transgenic mice.
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