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产品名称
起订量
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起订数量
产品概述
产品信息
| 别名 | Interleukin-36 gamma; IL36G; IL-1-related Protein 2; IL-1RP2; IL-1 epsilon; IL-1F9; Interleukin-1 homolog 1; IL-1H1 |
| 物种 | Human |
| 表达宿主 | E.coli |
| 序列信息 | Ser18-Asp169 |
| 检索号 | Q9NZH8 |
| 分子量 | 17.0 kDa |
| 表观分子量 | 14-16 kDa |
| 生物活性 | Measured by its ability to induce IL-8 secretion in A431 human epithelial carcinoma cells. The ED50 for this effect is less than 20 ng/ ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM Tris,100mM Nacl,0.1mM EDTA,pH8.0. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Interleukin-36 gamma (IL-36γ) is a member of the Interleukin 1 Cytokine family that includes three closely related genes, IL-36α, β, and γ, formerly known as IL-1F6, F8, and F9 respectively. IL-36α has been detected in both neuronal and synovial tissue, whereas IL-36β and IL-36γ are expressed in both cutaneous and mucosal epithelial cells, including the respiratory tract. IL-36β and IL-36γ stimulate proliferation, maturation and/ or Cytokine expression by innate immune cells (such as keratinocytes and dendritic cells), and adaptive immune cells (neutrophils and T-cells) in both humans and mice. The activity of IL-36α is mediated by Interleukin 1 Receptor-like 2 (IL1RL2/ IL1R-rp2), and is specifically inhibited by Interleukin 1 family, member 5 (IL1F5/ IL-1 delta). IL-36γ plays an important role in communicating the cell death to surrounding cells.
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