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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Interleukin-37; FIL1 Zeta; IL-1X; Interleukin-1 Family Member 7; IL-1F7; Interleukin-1 Homolog 4; IL-1H; IL-1H4; Interleukin-1 Zeta; IL-1 Zeta; Interleukin-1-Related Protein; IL-1RP1; Interleukin-23; IL-37; IL37; FIL1Z; IL1F7; IL1H4; IL1RP1 |
| 物种 | Human |
| 表达宿主 | E.coli |
| 序列信息 | Lys53-Asp218 |
| 检索号 | Q9NZH6 |
| 分子量 | 18.7 kDa |
| 表观分子量 | 18 kDa |
| 生物活性 | Measured by its ability to bind Human IL-18R beta in functional ELISA. The ED50 for this effect is less than 10 ug/ ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 2mM DTT, pH 7.4. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Human Interleukin family 1 Member 7 (IL1F7) is a member of the Interleukin 1 Cytokine family. Five alternatively spliced transcript variants encoding distinct isoforms have been reported with distinct expression profiles. The longest IL1F7 transcript, referred to as IL1F7b or IL1F7 isoform 1, encodes a 218 amino acid residues pro Protein containing a 45 amino acid propeptide, which is cleaved to generate mature Protein. IL1F7b binds to IL18 Rα with low affinity but does not exert any IL18 agonistic or antagonistic effects. IL1F7b also binds Interleukin 18 binding Protein (IL-18BP), an inhibitory binding Protein of Interleukin 18 (IL-18), and subsequently forms a complex with IL18 Receptor beta subunit, and through which it inhibits the activity of IL-18.
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