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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Sonic Hedgehog Protein; SHH; HHG-1; SHH |
| 物种 | Human |
| 表达宿主 | E.coli |
| 序列信息 | Cys24-Gly197 (Cys24Ile-Ile) |
| 检索号 | Q15465 |
| 分子量 | 19.8 kDa |
| 表观分子量 | 20 kDa |
| 生物活性 | Measured by its ability to bind Human BOC in functional ELISA. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 100mM NaCl, 1mM DTT, pH 7.5. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Sonic Hedgehog Homolog (SHH) belongs to a three- Protein family called Hedgehog. The other two family members are Indian Hedgehog (IHH) and Desert Hedgehog (DHH). Hedgehog Proteins are key signaling molecules in embryonic development. SHH is expressed in various embryonic tissues and plays critical roles in regulating the patterning of many systems, such as limbs and brain. SHH also plays an important role in adult, including the division of adult stem cells and the development of certain cancers and other diseases. Human SHH is expressed as a 45kDa precursor, and undergoes a series of processing during secretion. After the removal of the signal peptide, a protease within the C-terminal domain catalyzes the cleavage of SHH into a 20 kDa N-terminal signaling domain (SHH-N) and a 25 kDa C-terminal domain (SHH-C). SHH-N has the “all signaling” capability. SHH-N binds to the 12 pass transmembrane Protein Patched (Ptc) on cell surface, which releases the repression of the activity of Smoothened (Smo), a G- Protein coupled Receptor, by Ptc.
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