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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Tumor necrosis factor Receptor superfamily member 1B; TNFRSF1B; Tumor necrosis factorReceptor 2; TNF-R2; TNF-RII; Tumor necrosis factor Receptor type II; p75; p80 TNF-alphaReceptor; CD120b |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Pro24-Thr206 |
| 检索号 | P20333 |
| 分子量 | 46.5 kDa |
| 表观分子量 | 60 kDa |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Tumor necrosis factor Receptor superfamily member 1B (TNFRSF1B) is a member of the tumor necrosisfactor Receptor superfamily. Human TNF RII contains four cysteinerich repeats in its ECD, which shares 58%and 56% amino acid sequence identity with the mouse and rat orthologs, respectively.TNF RII is expressedpredominantly on cells of the hematopoietic lineage, such as T and natural killer cells, as well as onendothelial cells, microglia, astrocytes,neurons, oligodendrocytes, cardiac myocytes, thymocytes, andmesenchymal stem cells.TNF RII binds to the membranebound forms of TNFα and Lymphotoxinα/ TNFβ?soluble TNF is thought to signal predominately through TNF RI.Soluble TNF RII is believed to inhibit TNFbiological activity by binding TNF thereby preventing it from activating membrane TNF Receptors.
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