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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Tumor necrosis factor Receptor superfamily member 1B; Tumor necrosis factor Receptor 2; Tumor necrosis factor Receptor type II; p75; p80 TNF-alpha Receptor; TBP-2; TBPII; TNFRSF1B; TNFBR; TNFR2 |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Leu23-Asp257 |
| 检索号 | P20333 |
| 分子量 | 26.2 kDa |
| 表观分子量 | 40 kDa |
| 生物活性 | Measured by its ability to inhibit TNFa-mediated cytotoxicity using L?929 mouse fibroblast cells treated with TNFaThe ED50 for this effect is less than 0.6 μg/ mL. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Tumor necrosis factor Receptor superfamily member 1B is a 461 amino acids Protein that belongs to the TNFR (tumor necrosis factor Receptor) superfamily characterized by cysteine-rich extracellular domains. It contains 4 TNFR-Cys repeats. TNFRII is expressed in fetal brain. TNFRII is strongly expressed at the cartilage-pannus junction, and plays a major role in a subset of families with multiple cases of rheumatoid arthritis (RA). This Receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
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