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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Growth-regulated alpha Protein; C-X-C Motif Chemokine 1; Platelet-Derived Growth Factor-inducible Protein KC; Secretory Protein N51; Cxcl1; Gro; Gro1; Mgsa; Scyb1 |
| 物种 | Mouse |
| 表达宿主 | Human Cells |
| 序列信息 | Arg20-Lys96 |
| 检索号 | P12850 |
| 分子量 | 9.4 kDa |
| 表观分子量 | 11—13 kDa |
| 标签 | C-6His |
| 生物活性 | Testing in progress |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Growth-regulated alpha Protein (CXCL1,KC), is a member of the alpha Chemokine subfamily, was initially identified as an immediate early gene induced in mouse fibroblasts by platelet-Derived Growth Factor. The N-terminal processed form KC (5-72) of the Protein is produced by proteolytic cleavage after secretion from bone marrow stromal cells, and shows a highly enhanced hematopoietic activity. Mouse KC shows approximately 63% identity to that of mouse MIP-2. KC is also approximately 60% identical to the human GROs. It has been suggested that mouse KC and MIP-2 are the orthologs of the human GROs and rat CINCs. Cxcl1 has chemotactic activity for neutrophils, and contributes to neutrophil activation during inflammation. Hematoregulatory Chemokine, in vitro, suppresses hematopoietic progenitor cell proliferation.
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