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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Interleukin-1 Receptor type 2; IL-1R-2; IL-1RT-2; IL-1RT2; CD121 antigen-like family member B; CD121b; IL-1 type II Receptor; Interleukin-1 Receptor beta; IL-1R-beta; Interleukin-1 Receptor type II; CD121b |
| 物种 | Mouse |
| 表达宿主 | Human Cells |
| 序列信息 | Phe14-Glu355 |
| 检索号 | P27931 |
| 分子量 | 64.9 kDa |
| 表观分子量 | 85-110&140 kDa |
| 标签 | C-Fc |
| 生物活性 | Testing in progress |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Mouse Interleukin 1 Receptor, type II (IL1R2) is a Cytokine Receptor that belongs to the Interleukin-1 Receptor family. This Protein binds Interleukin alpha (IL1A), Interleukin beta (IL1B), and Interleukin 1 Receptor, type I (IL1R1/ IL1RA), and acts as a decoy Receptor that inhibits the activity of its Ligands. IL-1R2 structurally consisting of a Ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain. It is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Mouse IL1RII shares 59% amino acid sequence homology with human IL1 RII in their extracellular domains. The pleiotropic Cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane Receptors on cells. Two distinct types of IL1 Receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2 has no signaling property and acts as a decoy for IL-1.
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