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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Interleukin-23 Receptor; Il23r; IL-23 Receptor; IL-23R; Interleukin 23 Receptor |
| 物种 | Mouse |
| 表达宿主 | Human Cells |
| 序列信息 | Gly24-Asp372 |
| 检索号 | Q8K4B4 |
| 分子量 | 67.3 kDa |
| 表观分子量 | 90-110 kDa |
| 标签 | C-Fc |
| 生物活性 | Testing in progress |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Interleukin 23 Receptor (IL23R), a heterodimer of the IL12 Receptor β1 (IL12Rβ1) and IL12Rβ2, is a type I Cytokine Receptor for IL23. IL23R is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several Cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, and macrophages. In fact, polymorphisms of the IL23R gene were reported to be associated with susceptibility to inflammatory diseases and autoimmune diseases such as psoriasis, multiple sclerosis, Graves's ophtalmopathy and inflammatory bowel diseases. The IL23R is known to be critically involved in the carcinogenesis of different malignant tumor.
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