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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Interleukin 33; IL-33; IL33; C9orf26; NKHEV; Interleukin-1 family member 11; DVS27; NF-HEV and IL- 1F11 |
| 物种 | Mouse |
| 表达宿主 | E.coli |
| 序列信息 | Ser109-Ile266 |
| 检索号 | Q8BVZ5 |
| 分子量 | 17.6 kDa |
| 表观分子量 | 18 kDa |
| 生物活性 | Measured by its ability to bind Mouse IL-1 R4 in functional ELISA. Immobilized recombinant Mouse IL33 at 5 μg/ mL can bind Mouse IL1RL1with a linear range of 0.625-5ug/ ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory Cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identified based on sequence and structural homology with IL-1 family Cytokines. It is up-regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL-1 beta stimulation. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 Cytokines and acts through the Receptor IL1RL-1. BindingIL-33 to this Receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce Cytokines. In vivo, IL-33 induces the expression of IL-4, IL-5, IL-13 and also leads to severe pathological changes in mucosal organs.
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