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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
产品概述
产品信息
| 别名 | Interleukin-36 alpha; Il36a; FIL1 epsilon; Interleukin-1 epsilon; IL-1 epsilon; nterleukin-1 family member 6; IL-1F6; Interleukin-1 homolog 1; IL-1H1; Fil1e; Il1e; Il1f6; Il1h1 |
| 物种 | Mouse |
| 表达宿主 | E.coli |
| 序列信息 | Arg8-H |
| 检索号 | Q9JLA2 |
| 分子量 | 17.3 kDa |
| 表观分子量 | 16 kDa |
| 生物活性 | Testing in progress |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 复融 | Please refer to it for detailed information. |
背景介绍
Interleukin-36 alpha (Il-36a) is a member of the IL-1 family.IL?1α,IL?1β and IL-18 are potent inflammatory Cytokines whose activities are dependent on heterodimeric Receptors of the IL-1R superfamily, and which are regulated by soluble antagonists. Il36a is a Cytokine that binds to and signals through the IL1RL2/ IL-36R Receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. It is a part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coReceptor IL1RAP. It seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. It Induces the production of proinflammatory Cytokines, including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23 in bone marrow-Derived dendritic cells (BMDCs). Moreover, it is involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II and can induce the production of IFN-gamma, IL-4 and IL-17 by cultured CD4+ T cells and splenocytes. Il36a may play a role in proinflammatory effects in the lung: induces the expression of CXCL1 and CXCL2 in the lung, and the expression of TNF-alpha, IL-36c, IL-1A, IL-1B, CXCL1 and CXCL2 in isolated splenic CD11c+ alveolar macrophages. It may be involved in T cell maturation by stimulating the surface expression of CD40 and modestly CD80 and CD86 in splenic CD11c+ cells and CD4+ T cell proliferation.
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