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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
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Recombinant Human CD31/PECAM-1/Platelet EndotheliaGV-P00485-10ug￥ 620.001
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Recombinant Human CD31/PECAM-1/Platelet EndotheliaGV-P00485-50ug￥ 1800.001
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Recombinant Human CD31/PECAM-1/Platelet EndotheliaGV-P00485-500ug￥ 7200.001
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Recombinant Human CD31/PECAM-1/Platelet EndotheliaGV-P00485-1mg￥ 10400.001
产品简介
| 中文名称 | Recombinant Human CD31/PECAM-1/Platelet Endothelial Cell Adhesion Molecule |
| Known as | Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA; PECA1; CD31; PECAM1 |
| Derived from | Human Cells |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, 1mM EDTA，pH7.4. |
| Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Reconstitution | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Endotoxin | Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test. |
| Background | Platelet Endothelial Cell Adhesion Molecule (PECAM1, CD31),is a heavily glycosylated transmembrane protein belonging to theimmunoglobulin (Ig) superfamily of cell adhesion molecules. CD31 is composed of an extracellular domain (ECD) of 574 amino acids (aa) containing six Ig-likedomains, a transmembrane domain, and a 118 aacytoplasmic domain. CD31 is highly expressed on endothelial cells and at a lower level on platelets, granulocytes,macrophages, dendritic cells, T and B cells, and natural killer (NK) cells. It is involved in cell adhesion and is required for transepithelial migration of leukocytes (TEM). CD31 acts as a homophilic receptor through itsextracellular domain and is involved in downstream signaling via its cytoplasmic domain. This domain contains highly conserved ITIM motifs which, once tyrosinephosphorylated, recruit and activate the signaling molecules Src and SHP2. The resulting inhibition of TCR signaling increases the activation threshold ofT cells, thus reinforcing peripheral tolerance and preventing development of autoimmunity. CD31 additionally regulates immune responses by acting as a keyinhibitory receptor in dendritic cell development. CD31 is required for the transendothelial migration of leukocytes through intercellular junctions of vascular endothelial cells. |
| 规格 | 10ug50ug500ug1mg |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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