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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
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Recombinant Mouse Kirrel1/NEPH1/nephrin-like proteGV-P00584-10ug￥ 844.001
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Recombinant Mouse Kirrel1/NEPH1/nephrin-like proteGV-P00584-50ug￥ 2520.001
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Recombinant Mouse Kirrel1/NEPH1/nephrin-like proteGV-P00584-500ug￥ 9600.001
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Recombinant Mouse Kirrel1/NEPH1/nephrin-like proteGV-P00584-1mg￥ 11200.001
产品简介
| 中文名称 | Recombinant Mouse Kirrel1/NEPH1/nephrin-like protein 1 |
| Known as | Kin of IRRE-like protein 1;Kin of irregular chiasm-like protein 1;Nephrin-like protein 1;Kirrel1;Neph1 |
| Derived from | Human Cells |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS,pH 7.4. |
| Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Reconstitution | Dissolve the lyophilized protein in distilled water. |
| Endotoxin | Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test. |
| Background | Kin of irregular chiasm-like protein 1(Kirrel1), also known as Nephrin-like protein 1(Neph1), belongs to the immunoglobulin superfamily. Kirrel1 plays a significant role in the normal development and function of the glomerular permeability. It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. The knockout of this gene could result in perinatal lethality accompanied by proteinuria, and effacement of glomerular podocytes. Kirrel1 is abundantly expressed in kidney and specifically expressed in podocytes of kidney glomeruli. Its’ subunit interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus) and interacts with NPHS1/nephrin (via the Ig-like domains). This interaction is dependent on KIRREL glycosylation. Kirrel1 also interacts when tyrosine-phosphorylated with GRB2. |
| 规格 | 10ug50ug500ug1mg |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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