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产品名称
起订量
单价(含增值税)
库存(PCS)
起订数量
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Recombinant Human CCND2/G1/S-specific cyclin-D2100ml/瓶￥ 11
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Recombinant Human CCND2/G1/S-specific cyclin-D2400ml￥ 11
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Recombinant Human CCND2/G1/S-specific cyclin-D2GV-P01263-10ug￥ 1176.001
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Recombinant Human CCND2/G1/S-specific cyclin-D2GV-P01263-50ug￥ 3720.001
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Recombinant Human CCND2/G1/S-specific cyclin-D2GV-P01263-500ug￥ 13520.001
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Recombinant Human CCND2/G1/S-specific cyclin-D2GV-P01263-1mg￥ 18800.001
产品简介
| Known as | G1/S-specific cyclin-D2;CCND2; |
| Derived from | E.coli |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,5mM DTT,pH7.5. |
| Storage | Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening.Please minimize freeze-thaw cycles. |
| Endotoxin | Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test. |
| Background | CCND2，also known as G1/S-specific cyclin-D2，is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND2 is involved in a number of fundamental biological processes such as phosphorylating and inhibiting members of the retinoblastoma (RB) protein family including RB1 and regulating the cell-cycle during G1/S transition. It is also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. |
| 规格 | 10ug50ug500ug1mg |
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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